Document Detail

Oestradiol-induced hypotension in spontaneously hypertensive rats: putative role for intracellular cations, sodium-potassium flux and prostanoids.
MedLine Citation:
PMID:  1315649     Owner:  NLM     Status:  MEDLINE    
1. The effect of oestradiol alone and in combination with indomethacin on blood pressure, erythrocyte cation concentration and Na(+)-K+ flux has been studied in adult female normotensive and spontaneously hypertensive rats. 2. Oestradiol alone resulted in a significant decrease in blood pressure in spontaneously hypertensive rats (from 165.3 +/- 3.9 to 146.4 +/- 2.7 mmHg, P less than 0.001), whereas it induced a significant increase in normotensive rats (from 111.8 +/- 1.8 to 124.1 +/- 3.6 mmHg, P less than 0.001). When indomethacin and oestradiol were administered simultaneously or when indomethacin was given alone, no change in blood pressure occurred in spontaneously hypertensive rats (158.6 +/- 6.9 and 159.8 +/- 6.2 mmHg, respectively). 3. The fall in blood pressure induced by oestradiol in spontaneously hypertensive rats was associated with significant reductions in erythrocyte K+ concentration (from 127.4 +/- 1.2 to 116.9 +/- 1.7 mmol/l of cells, P less than 0.001), in erythrocyte Na+ concentration (from 14.3 +/- 0.8 to 13.0 +/- 0.6 mmol/l of cells, P less than 0.02), in ouabain-sensitive erythrocyte Na+ flux (from 17.8 +/- 0.3 to 16.0 +/- 0.4 mmol h-1 (l of cells)-1, P less than 0.01) and in ouabain-sensitive erythrocyte K+ flux (from 11.4 +/- 0.2 to 10.4 +/- 0.2 mmol h-1 (l of cells)-1, P less than 0.01). No change in blood pressure, erythrocyte cation concentration or Na(+)-K+ flux occurred when oestradiol and indomethacin were given together or when indomethacin was administered alone.(ABSTRACT TRUNCATED AT 250 WORDS)
C Stonier; J Bennett; E A Messenger; G M Aber
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinical science (London, England : 1979)     Volume:  82     ISSN:  0143-5221     ISO Abbreviation:  Clin. Sci.     Publication Date:  1992 Apr 
Date Detail:
Created Date:  1992-06-11     Completed Date:  1992-06-11     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7905731     Medline TA:  Clin Sci (Lond)     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  389-95     Citation Subset:  IM    
School of Postgraduate Medicine and Biological Sciences, University of Keele, Stoke-on-Trent, U.K.
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MeSH Terms
Blood Pressure / drug effects
Body Weight / drug effects
Erythrocytes / metabolism
Estradiol / pharmacology*
Hypotension / chemically induced*
Indomethacin / pharmacology
Potassium / blood*
Rats, Inbred SHR
Renin / blood
Sodium / blood*
Sodium-Potassium-Exchanging ATPase / physiology
Reg. No./Substance:
50-28-2/Estradiol; 53-86-1/Indomethacin; 7440-09-7/Potassium; 7440-23-5/Sodium; EC; EC ATPase

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