| Oesophago-gastric junction opening function: assessment using ultrasound imaging and the effects of atropine. | |
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MedLine Citation:
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PMID: 16629865 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Relaxation and opening of the oesophago-gastric junction (OGJ) is crucial for oesophageal transport. A novel ultrasound technique was used to determine OGJ opening, before and after atropine, in 12 normals. An ultrasound probe, a solid-state pressure transducer and an infusion tube were placed inside a 20-mm diameter bag, which was placed across the OGJ. At various bag pressures ultrasound transducer was pulled across the bag. Acquired B-mode ultrasound images were converted into M-mode image to display the oesophagus, OGJ and stomach. At low bag-pressure (< 20 mmHg), the OGJ but not oesophagus and stomach, is collapsed around the bag. Increasing bag pressure results in gradual opening of the OGJ from distal end. M-mode image identified the narrowest region of OGJ and corresponding cross-sectional area (CSA) was measured. Mean bag pressure to initial OGJ opening was 18 mmHg. Linear relationship between bag-pressure and OGJ-CSA was observed. Atropine reduced opening bag pressure and shifted the OGJ pressure-CSA curve upward without altering slope, i.e. compliance. Our novel ultrasound technique to study the OGJ opening function shows two distinct components; firstly, related to the tonic OGJ contraction and secondly, to passive or viscoelastic properties of the OGJ. |
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Authors:
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J Liu; T Takeda; I Dogan; V Bhargava; R K Mittal |
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Publication Detail:
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Type: In Vitro; Journal Article; Research Support, N.I.H., Extramural; Validation Studies |
Journal Detail:
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Title: Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society Volume: 18 ISSN: 1350-1925 ISO Abbreviation: Neurogastroenterol. Motil. Publication Date: 2006 May |
Date Detail:
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Created Date: 2006-04-24 Completed Date: 2006-06-23 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 9432572 Medline TA: Neurogastroenterol Motil Country: England |
Other Details:
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Languages: eng Pagination: 376-84 Citation Subset: IM |
Affiliation:
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Division of Gastroenterology, University of California, San Diego and San Diego VA HealthCare System, San Diego, CA 92161, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Atropine / pharmacology* Compliance / drug effects Endosonography / instrumentation, methods* Esophagogastric Junction / drug effects*, physiology*, ultrasonography* Female Humans Male Muscarinic Antagonists / pharmacology* |
| Grant Support | |
ID/Acronym/Agency:
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R0-1 DK60733/DK/NIDDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Muscarinic Antagonists; 51-55-8/Atropine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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