Document Detail


Oesophageal wall stretch: the stimulus for distension induced oesophageal sensation.
MedLine Citation:
PMID:  15601421     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Recently, we reported a novel ultrasound technique to assess the biomechanical properties of the oesophagus in humans. To investigate whether the oesophageal sensation induced by oesophageal distension correlates with wall tension, wall stress or wall strain, we studied 20 healthy subjects using a manometry catheter equipped with a high-compliance bag and a high-frequency intraluminal ultrasound probe. Oesophageal distensions were performed by injecting 1-20 mL water into the bag for 20-30 s. Subjects scored the nature (heartburn or chest pain) and severity of sensation in response to distension, before and after atropine (15 microg kg(-1), i.v.). Ultrasound images of oesophagus were digitized and measurements were made to calculate oesophageal wall tension, stress and strain during distensions. Subjects experienced mostly heartburn, not chest pain, in response to oesophageal distension. Oesophageal wall strain and bag pressures correlated best with the oesophageal sensation. Atropine reduced bag pressure but did not affect the distension induced heartburn and chest pain. We conclude that heartburn is a common sensation in response to oesophageal distension in normal subjects. A strong correlation between wall strain and oesophageal sensation suggests that the wall stretch is the stimulus for nociceptive mechanoreceptors of the oesophagus.
Authors:
T Takeda; T Nabae; G Kassab; J Liu; R K Mittal
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society     Volume:  16     ISSN:  1350-1925     ISO Abbreviation:  Neurogastroenterol. Motil.     Publication Date:  2004 Dec 
Date Detail:
Created Date:  2004-12-16     Completed Date:  2005-02-01     Revised Date:  2006-11-07    
Medline Journal Info:
Nlm Unique ID:  9432572     Medline TA:  Neurogastroenterol Motil     Country:  England    
Other Details:
Languages:  eng     Pagination:  721-8     Citation Subset:  IM    
Affiliation:
Division of Gastroenterology, San Diego VA Medical Centre, San Diego, CA 92161, USA.
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MeSH Terms
Descriptor/Qualifier:
Adult
Balloon Dilatation*
Chest Pain / etiology
Compliance
Esophagus / physiology*
Female
Heartburn / etiology*
Humans
Male
Manometry
Sensation / physiology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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