| Oesophageal varices in cirrhotic patients: from variceal screening to primary prophylaxis of the first oesophageal variceal bleeding. | |
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MedLine Citation:
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PMID: 20946450 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Bleeding from oesophageal varices is still a lethal complication in cirrhotic patients with portal hypertension. Approximately 5-10% of patients with cirrhosis will develop oesophageal varices per year, and about 25-30% of cirrhotic patients with oesophageal varices and without previous variceal haemorrhage will bleed from ruptured varices. To date, data on preventing the formation/growth of oesophageal varices (preprimary prophylaxis) are conflicting, with insufficient evidence to use β-blockers. There is evidence for the need for primary prophylaxis, and both β-blockers and endoscopic variceal ligation have shown the same efficacy in preventing first bleeding, but which one to prefer is still controversial. The present article reviews the established and potential therapeutic strategies for preventing the development and rupture of oesophageal varices. |
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Authors:
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Chunqing Zhang; Dominique Thabut; Patrick S Kamath; Vijay H Shah |
Publication Detail:
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Type: Journal Article; Review Date: 2010-10-14 |
Journal Detail:
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Title: Liver international : official journal of the International Association for the Study of the Liver Volume: 31 ISSN: 1478-3231 ISO Abbreviation: Liver Int. Publication Date: 2011 Jan |
Date Detail:
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Created Date: 2010-12-06 Completed Date: 2011-03-21 Revised Date: 2012-05-17 |
Medline Journal Info:
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Nlm Unique ID: 101160857 Medline TA: Liver Int Country: England |
Other Details:
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Languages: eng Pagination: 108-19 Citation Subset: IM |
Copyright Information:
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© 2010 John Wiley & Sons A/S. |
Affiliation:
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Department of Gastroenterology, Provincial Hospital Affiliated to Shandong University, Jinan Shandong, China. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adrenergic beta-Antagonists
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adverse effects,
therapeutic use* Endoscopy, Gastrointestinal* / adverse effects Esophageal and Gastric Varices / diagnosis, etiology, physiopathology, therapy* Gastrointestinal Hemorrhage / etiology, physiopathology, prevention & control* Hemodynamics Humans Hypertension, Portal / etiology*, physiopathology Ligation Liver Cirrhosis / complications*, physiopathology Mass Screening* / methods Risk Factors Treatment Outcome |
| Grant Support | |
ID/Acronym/Agency:
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R01 DK059615/DK/NIDDK NIH HHS; R01 DK059615-09/DK/NIDDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Adrenergic beta-Antagonists |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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