Document Detail

Oesophageal pH-metry: should meals be standardized?
MedLine Citation:
PMID:  1529267     Owner:  NLM     Status:  MEDLINE    
To assess the effect of a late-evening, high-fat meal on nocturnal supine gastro-oesophageal reflux, eight healthy volunteers (aged 20 to 38 years) underwent two ambulatory oesophageal pH-metry recordings, the first after a standardized light meal at 1930 h and the second after a high-fat meal including peppermint and chocolate, at 2130 h. Between 2300 and 0700 h, when subjects were supine, the median acid exposure time (percentage recording with pH less than 4) increased from 0.0% (range, 0.0-6.8%) after the standardized meal to 7.9% (0.0-17.8%) after the high-fat meal (p = 0.031). Similarly, the median number of reflux episodes increased from 0 (0 to 11) after the standardized meal to 7 (0 to 26) after the high-fat meal (p = 0.031). Reflux occurred after both meals, but, in general, persistent nocturnal reflux was observed only after the high-fat meal. Thus, the analysis of oesophageal pH recordings should consider the effects of meal composition and timing on oesophageal acid exposure.
F Castiglione; C Emde; D Armstrong; P Bauerfeind; C Schneider; G Stacher; A L Blum
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Scandinavian journal of gastroenterology     Volume:  27     ISSN:  0036-5521     ISO Abbreviation:  Scand. J. Gastroenterol.     Publication Date:  1992 May 
Date Detail:
Created Date:  1992-10-19     Completed Date:  1992-10-19     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0060105     Medline TA:  Scand J Gastroenterol     Country:  NORWAY    
Other Details:
Languages:  eng     Pagination:  350-4     Citation Subset:  IM    
Division of Gastroenterology, CHUV, Lausanne, Switzerland.
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MeSH Terms
Dietary Fats / adverse effects
Gastroesophageal Reflux / chemically induced,  diagnosis*
Hydrogen-Ion Concentration
Time Factors
Reg. No./Substance:
0/Dietary Fats

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