Document Detail


Oesophageal heat transfer properties indication of segmental blood flow changes during distension.
MedLine Citation:
PMID:  18004987     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The pain perception to distension of the oesophagus can be explained by activation of receptors responding to mechanical deformation or to distension-induced ischaemia. The aim of this study was to develop a new method for detection of changes in segmental blood flow during distension based on measurement of heat transfer. A bag was distended in the distal oesophagus of six healthy subjects followed by cooling or heating of the bag fluid to 5 or 60 degrees C. After equilibrium, the temperature was allowed to change back to body temperature. The temperature was recorded together with intraluminal ultrasound imaging, allowing assessment of the heat transfer properties at different bag volumes. The heat transfer constants were higher after heating the bag than after cooling the bag (Tukey, P < 0.05). The heat transfer constants after heating the bag decreased as function of bag volumes whereas the heat transfer during cooling was not affected by the bag volume (F = 0.9, P = 0.4). The findings indicate that segmental blood flow can be assessed indirectly by calculating the heat transfer properties. Distension induced a drop in regional blood flow. Hence, ischaemia may contribute to distension-induced pain. Furthermore, heat increased segmental blood flow and cold decreased segmental blood flow. This method may in the future be used to explore the mechanisms behind oesophageal pain.
Authors:
D Liao; J B Frøkjaer; C Brock; S D Andersen; A M Drewes; H Gregersen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-11-14
Journal Detail:
Title:  Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society     Volume:  20     ISSN:  1365-2982     ISO Abbreviation:  Neurogastroenterol. Motil.     Publication Date:  2008 Apr 
Date Detail:
Created Date:  2008-03-28     Completed Date:  2008-07-08     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  9432572     Medline TA:  Neurogastroenterol Motil     Country:  England    
Other Details:
Languages:  eng     Pagination:  298-303     Citation Subset:  IM    
Affiliation:
Center of Excellence in Visceral Biomechanics and Pain, Aalborg Hospital, Aalborg, Denmark. dliao@hst.aau.dk
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MeSH Terms
Descriptor/Qualifier:
Adult
Dilatation, Pathologic
Esophagus / blood supply*,  physiology*
Female
Hot Temperature*
Humans
Male
Manometry / instrumentation,  methods
Middle Aged
Pain Threshold
Regional Blood Flow
Sensation / physiology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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