| Oesophageal dysfunction in familial amyloidosis with polyneuropathy. | |
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MedLine Citation:
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PMID: 8435977 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Sixteen patients with familial amyloidosis and polyneuropathy (FAP) and 14 health subjects underwent oesophageal manometry. Six of the patients had a severe oesophageal dysmotility with almost completely abolished propulsive pressure waves on swallowing in the lower 2/3 of the oesophagus. Ten patients had moderate dysfunction with reduced propulsive pressure wave amplitudes. Neostigmine increased the pressure wave amplitudes in healthy subjects but less so in the FAP patients. Scopolamine (Scopyl)-terbutaline (Bricanyl) almost abolished the propulsive pressure waves in healthy subjects and all patients in the lower 2/3 of the esophagus. Oesophageal distensibility, tested by inflating a rubber balloon in the oesophagus, was similar in FAP patients and healthy subjects. Thus, it is unlikely that amyloid deposits in the mucosal wall increased the oesophageal stiffness. An autonomic, predominantly vagal, denervation probably explains the disturbed function. |
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Authors:
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P Bjerle; B Ek; H Linderholm; L Steen |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Clinical physiology (Oxford, England) Volume: 13 ISSN: 0144-5979 ISO Abbreviation: Clin Physiol Publication Date: 1993 Jan |
Date Detail:
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Created Date: 1993-03-19 Completed Date: 1993-03-19 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8309768 Medline TA: Clin Physiol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 57-69 Citation Subset: IM |
Affiliation:
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Department of Clinical Physiology, University of Umeå, Sweden. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Amyloidosis / complications*, genetics Deglutition Esophageal Diseases / etiology*, physiopathology Female Gastrointestinal Motility Humans Male Manometry Middle Aged Muscle Relaxation / drug effects, physiology Neostigmine / pharmacology Nervous System Diseases / complications* Scopolamine / pharmacology Terbutaline / pharmacology |
| Chemical | |
Reg. No./Substance:
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23031-25-6/Terbutaline; 51-34-3/Scopolamine; 59-99-4/Neostigmine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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