Document Detail

Oedema, Starling and pulse reverse osmosis: towards a possible biochemical marker for oedema.
MedLine Citation:
PMID:  10357241     Owner:  NLM     Status:  MEDLINE    
Several conflicting theories have been proposed to explain the development of oedema. Pulse reverse osmosis (PRO) suggests that oedema occurs when the mean pulse capillary pressure exceeds the osmotic gradient between the plasma and the interstitial fluid. In order to test this concept mean arterial blood pressures and colloid osmotic pressures were taken in a group of healthy volunteers, a group of patients with bilateral ankle oedema and a group of treated hypertensives. Patients with oedema were found to have colloid osmotic pressures (COP's) which were significantly less than those of the healthy volunteers (p <0.001) and the treated hypertensives (p <0.001). The results support the oedema mechanism proposed by PRO and indicate that the relationship between blood pressure and COP may be a useful biochemical marker of oedema and its treatment. Further study is required to numerically quantify this relationship.
F G Prior; V Morecroft; R Fergusson; T Gourlay; K M Taylor
Publication Detail:
Type:  Clinical Trial; Comparative Study; Controlled Clinical Trial; Journal Article    
Journal Detail:
Title:  The International journal of artificial organs     Volume:  22     ISSN:  0391-3988     ISO Abbreviation:  Int J Artif Organs     Publication Date:  1999 Mar 
Date Detail:
Created Date:  1999-07-29     Completed Date:  1999-07-29     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7802649     Medline TA:  Int J Artif Organs     Country:  ITALY    
Other Details:
Languages:  eng     Pagination:  138-44     Citation Subset:  IM    
The Osmosis Unit, CIHT, Caledonian University, Glasgow, Scotland.
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MeSH Terms
Analysis of Variance
Biological Markers / analysis
Blood Pressure / physiology*
Body Fluids
Capillary Permeability / physiology*
Edema / etiology*,  physiopathology
Hypertension / complications*,  physiopathology
Osmolar Concentration
Osmotic Pressure*
Pulsatile Flow
Reference Values
Sensitivity and Specificity
Reg. No./Substance:
0/Biological Markers

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