Document Detail


Odorant and pheromone receptor gene regulation in vertebrates.
MedLine Citation:
PMID:  17709237     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The largest mammalian gene family codes for odorant receptors and is exclusively devoted to the perception of the outside world. Its expression is very peculiar, since olfactory sensory neurons are only allowed to express a single of its numerous members, from a single parental allele. How this is achieved is unknown, but recent work points to multiple regulatory mechanisms, possibly shared by pheromone receptor genes, acting at (a) a general level, via the expression of the chemoreceptor itself and (b) a more restricted level, defined by activator elements.
Authors:
Ivan Rodriguez
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2007-08-20
Journal Detail:
Title:  Current opinion in genetics & development     Volume:  17     ISSN:  0959-437X     ISO Abbreviation:  Curr. Opin. Genet. Dev.     Publication Date:  2007 Oct 
Date Detail:
Created Date:  2007-11-05     Completed Date:  2008-01-15     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9111375     Medline TA:  Curr Opin Genet Dev     Country:  England    
Other Details:
Languages:  eng     Pagination:  465-70     Citation Subset:  IM    
Affiliation:
Department of Zoology and Animal Biology, and NCCR Frontiers in Genetics, University of Geneva, Geneva, Switzerland. ivan.rodriguez@zoo.unige.ch
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MeSH Terms
Descriptor/Qualifier:
Animals
Gene Expression Regulation*
Receptors, Odorant / genetics*,  metabolism
Receptors, Pheromone / genetics*,  metabolism
Vertebrates / genetics*,  metabolism
Chemical
Reg. No./Substance:
0/Receptors, Odorant; 0/Receptors, Pheromone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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