Document Detail


Odor structure-activity relationships compared in human and nonhuman primates.
MedLine Citation:
PMID:  10571482     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The ability of 4 squirrel monkeys to distinguish between members of 3 homologous series of substances (aliphatic alcohols, aldehydes, and ketones) was investigated, and their performance was compared with that of a group of 10 human participants. With all 3 substance classes, and in both species, a significant negative correlation was found between discrimination performance and structural similarity of odorants in terms of differences in carbon chain length. These findings suggest carbon chain length of aliphatic odorants to be one of presumably several determinants of the interaction between stimulus molecule and olfactory receptor and support the assumption that human and nonhuman primates may share common mechanisms of odor quality perception.
Authors:
M Laska; S Trolp; P Teubner
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Behavioral neuroscience     Volume:  113     ISSN:  0735-7044     ISO Abbreviation:  Behav. Neurosci.     Publication Date:  1999 Oct 
Date Detail:
Created Date:  1999-12-02     Completed Date:  1999-12-02     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8302411     Medline TA:  Behav Neurosci     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  998-1007     Citation Subset:  IM    
Affiliation:
Department of Medical Psychology, University of Munich Medical School, Germany. Laska@imp.med.uni-muenchen.de
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MeSH Terms
Descriptor/Qualifier:
Adult
Alcohols / analysis*,  chemistry
Aldehydes / analysis*,  chemistry
Analysis of Variance
Animals
Discrimination Learning / physiology*
Female
Humans
Ketones / analysis*,  chemistry
Male
Odors / analysis*
Receptors, Odorant / physiology
Saimiri
Smell / physiology*
Structure-Activity Relationship
Chemical
Reg. No./Substance:
0/Alcohols; 0/Aldehydes; 0/Ketones; 0/Receptors, Odorant

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