Document Detail


Odor identification ability predicts executive function deficits following sleep deprivation.
MedLine Citation:
PMID:  20402570     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Odor identification ability is sensitive to prefrontal lobe dysfunction and preliminary evidence suggests that this capacity may decline with prolonged wakefulness. We hypothesized that declines in odor identification during a single night of sleep loss might, therefore, be predictive of prefrontal lobe executive function deficits following an additional night of sleep deprivation. Change scores between two administrations of the University of Pennsylvania Smell Identification Test (SIT) during 24 hr of sleep deprivation were used to predict performance on the Wisconsin Card Sorting Test (WCST) following 45 hr of wakefulness in 54 healthy adults. Declines in SIT performance predicted poorer performance on the WCST following an additional night of sleep loss. These findings suggest that individual differences in vulnerability to the effects of sleep loss on odor identification ability are predictive of deficits in executive functioning following additional wakefulness. Odor identification ability may provide an unobtrusive method for assessing vulnerability to sleep deprivation.
Authors:
William D S Killgore; Desiree B Killgore; Nancy L Grugle; Thomas J Balkin
Publication Detail:
Type:  Controlled Clinical Trial; Journal Article    
Journal Detail:
Title:  The International journal of neuroscience     Volume:  120     ISSN:  1563-5279     ISO Abbreviation:  Int. J. Neurosci.     Publication Date:  2010 May 
Date Detail:
Created Date:  2010-04-20     Completed Date:  2010-07-14     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0270707     Medline TA:  Int J Neurosci     Country:  England    
Other Details:
Languages:  eng     Pagination:  328-34     Citation Subset:  IM    
Affiliation:
Department of Behavioral Biology, Division of Psychiatry and Neuroscience, Walter Reed Army Institute of Research, Washington, DC, USA. killgore@mclean.harvard.edu
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MeSH Terms
Descriptor/Qualifier:
Benzhydryl Compounds / pharmacology
Caffeine / pharmacology
Central Nervous System Stimulants / pharmacology*
Dextroamphetamine / pharmacology
Executive Function / drug effects,  physiology*
Female
Humans
Male
Odors
Olfactory Perception / drug effects,  physiology*
Sleep Deprivation / psychology*
Time Factors
Young Adult
Chemical
Reg. No./Substance:
0/Benzhydryl Compounds; 0/Central Nervous System Stimulants; 51-64-9/Dextroamphetamine; 58-08-2/Caffeine; 68693-11-8/modafinil

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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