| Odor-concentration coding in the guinea-pig piriform cortex. | |
| | |
MedLine Citation:
|
PMID: 15590159 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
By optical imaging of intrinsic signals, we demonstrated a possible code for odor concentration in the anterior piriform cortex of the guinea-pig. Odor-induced cortical activation, which primarily originated in layer II, appeared in a narrow band beneath the rhinal sulcus over the lateral olfactory tract, corresponding to the dorsal part of the anterior piriform cortex. Lower concentrations activated the rostral region of the band, whereas higher ones generated caudally spreading activation, and the site at which neural activation reached its maximum extent depended upon odor concentration. Different odors with low concentrations generated distinct but somewhat overlapping patterns in the rostral region of the band; the limited extent of cortical activity may be one focal domain for each odor. It was hard to judge, however, that odor-specific domains appeared in the anterior piriform cortex, because the strong stimuli induced largely overlapping patterns. Furthermore, the total area activated increased in proportion to concentrations raised to a power of 0.5-0.9. Importantly, these imaging results were confirmed with unit recordings which indicated a rostro-caudal gradient in odor-sensitivity among cortical neurons. Our results suggest that the dorsal part of the anterior piriform cortex may be associated with odor concentration. Therefore, in addition to recruitment of more olfactory sensory cells and glomeruli in response to stronger stimuli, a rostro-caudal gradient in axonal projections from mitral/tufted cells and/or in association fibers may play an important role in odor-concentration coding in the anterior piriform cortex. |
| | |
Authors:
|
T Sugai; T Miyazawa; M Fukuda; H Yoshimura; N Onoda |
Related Documents
:
|
19523649 - Brain lesions induced by experimental intranasal infection of japanese encephalitis vir... 18817519 - From nose to brain: understanding transport capacity and transport rate of drugs. 18671299 - Sensory-dependent asymmetry for a urine-responsive olfactory bulb glomerulus. 12771169 - Olfactory input increases visual sensitivity in zebrafish: a possible function for the ... 6839159 - Experimental studies on the olfactory marker protein. iii. the olfactory marker protein... 14622239 - Taste-olfactory convergence, and the representation of the pleasantness of flavour, in ... 21904789 - Stem cell transplantation for motor neuron disease: current approaches and future persp... 19036989 - Postnatal differentiation of basket cells from slow to fast signaling devices. 23651839 - Cortical effects of user training in a motor imagery based brain-computer interface mea... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Neuroscience Volume: 130 ISSN: 0306-4522 ISO Abbreviation: Neuroscience Publication Date: 2005 |
Date Detail:
|
Created Date: 2004-12-13 Completed Date: 2005-03-01 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 7605074 Medline TA: Neuroscience Country: United States |
Other Details:
|
Languages: eng Pagination: 769-81 Citation Subset: IM |
Affiliation:
|
Department of Physiology, Kanazawa Medical University, Uchinada, Ishikawa 920-0293, Japan. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Brain Mapping Butanols / pharmacology Dose-Response Relationship, Drug Guinea Pigs Image Processing, Computer-Assisted Neurons Odors* Olfactory Pathways / cytology, physiology* Pentanols / pharmacology Signal Transduction / physiology Smell / physiology* Xylenes / pharmacology |
| Chemical | |
Reg. No./Substance:
|
0/Butanols; 0/Pentanols; 0/Xylenes; 628-63-7/amyl acetate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Neurochemical phenotype of vagal afferent neurons activated to express C-FOS in response to luminal ...
Next Document: Pre- and postsynaptic modulation of glycinergic and gabaergic transmission by muscarinic receptors o...