Document Detail

Odontogenic focal infection could be partly involved in the pathogenesis of atopic dermatitis as exacerbating factor.
MedLine Citation:
PMID:  17442076     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: A focal infection has been reported to be associated with the pathogenesis of various skin diseases, but, to date, not atopic dermatitis (AD). The objective of the study was to clarify whether the odontogenic focal infection (OFI) could be recognized as one of the exacerbating factors in AD. METHODS: Forty-three patients with AD whose skin conditions were resistant to conventional therapy were examined. An OFI was evaluated by using radiographs. Serum IgE/sCD30 levels were also examined. Skin condition was evaluated by the eczema area and severity index (EASI). RESULTS: Odontogenic focal infection was detected in 13 patients (30%) and this incidence was higher than in the normal population. Moreover, a 3-month therapy including dental care improved the skin conditions of patients with OFI better than those without OFI. CONCLUSION: The study concluded that OFI could be involved in the pathogenesis of some types of AD as exacerbating factors.
Ken Igawa; Kiyoshi Nishioka; Hiroo Yokozeki
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International journal of dermatology     Volume:  46     ISSN:  0011-9059     ISO Abbreviation:  Int. J. Dermatol.     Publication Date:  2007 Apr 
Date Detail:
Created Date:  2007-04-19     Completed Date:  2007-06-19     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0243704     Medline TA:  Int J Dermatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  376-9     Citation Subset:  IM    
Department of Dermatology, Tokyo Medical and Dental University, Tokyo, Japan.
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MeSH Terms
Dermatitis, Atopic / etiology*,  pathology
Immunoglobulin E / blood
Japan / epidemiology
Middle Aged
Mouth Diseases / blood,  complications,  epidemiology*,  pathology,  radiography
Severity of Illness Index
Reg. No./Substance:
37341-29-0/Immunoglobulin E

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