Document Detail


Odd-numbered medium-chain triglycerides (trinonanoin) in total parenteral nutrition: effects on parameters of fat metabolism in rabbits.
MedLine Citation:
PMID:  8301805     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Odd-numbered medium-chain triglycerides (MCTs) might combine the advantages of "usual" MCTs applied in clinical nutrition with lower ketogenic action and the release of three carbon units. To test subacute toxicity, trinonanoin/long-chain triglyceride (LCT) (7/3 wt/wt) fat emulsions were given to rabbits (n = 8) for 11 days (7 h/d) within a total parenteral nutrition regimen at a dose of 46.5% of total daily energy. Comparisons were made with rabbits receiving equicaloric amounts of MCT/LCT (7/3, wt/wt) or pure LCT fat emulsions, as well as with orally fed controls. The trinonanoin/LCT emulsion was well tolerated by all animals. Body weight changes showed no statistically significant differences between groups. The enzymatic determination of triglycerides, non-esterified fatty acids, and free glycerol concentrations in plasma samples revealed similar results for both MCT groups. However, ketone body concentrations (3-hydroxybutyrate) were significantly lower after trinonanoin/LCT emulsion administration. In the trinonanoin/LCT group, the plasma concentrations of propionic acid as well as of other short-chain fatty acids continuously increased; on days 10 and 11, elevated amounts of propionic acid were also detected in the urine. The histologic examination of the gut mucosa revealed no distinct differences between groups. On the basis of the presented data, the trinonanoin/LCT emulsion showed no inferiority to "usual" MCT/LCT emulsions. The lower ketogenic effect as well as the marked increase in plasma short-chain fatty acid concentrations may encourage further testing of this substrate for total parenteral nutrition.
Authors:
J Linseisen; G Wolfram
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  JPEN. Journal of parenteral and enteral nutrition     Volume:  17     ISSN:  0148-6071     ISO Abbreviation:  JPEN J Parenter Enteral Nutr     Publication Date:    1993 Nov-Dec
Date Detail:
Created Date:  1994-03-04     Completed Date:  1994-03-04     Revised Date:  2007-02-21    
Medline Journal Info:
Nlm Unique ID:  7804134     Medline TA:  JPEN J Parenter Enteral Nutr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  522-8     Citation Subset:  IM    
Affiliation:
Institute of Nutrition Science, Technical University of Munich, Freising-Weihenstephan, Germany.
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MeSH Terms
Descriptor/Qualifier:
3-Hydroxybutyric Acid
Acetoacetates / blood
Analysis of Variance
Animals
Butyrates / blood
Fat Emulsions, Intravenous / pharmacology*
Fatty Acids, Nonesterified / blood
Glycerol / blood
Hydroxybutyrates / blood
Lipid Metabolism*
Male
Parenteral Nutrition, Total*
Rabbits
Random Allocation
Triglycerides / blood,  pharmacology*
Chemical
Reg. No./Substance:
0/Acetoacetates; 0/Butyrates; 0/Fat Emulsions, Intravenous; 0/Fatty Acids, Nonesterified; 0/Hydroxybutyrates; 0/Triglycerides; 126-53-4/tripelargonin; 300-85-6/3-Hydroxybutyric Acid; 541-50-4/acetoacetic acid; 56-81-5/Glycerol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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