Document Detail

Oculomotor response inhibition abnormalities in pediatric obsessive-compulsive disorder.
MedLine Citation:
PMID:  9294374     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Disturbances in the orbital prefrontal cortex and its ventral striatal target fields have been identified in neuroimaging studies of obsessive-compulsive disorder (OCD). In animal models and studies of patients with lesions to this brain circuitry, a selective disturbance in the ability to suppress responses to irrelevant stimuli has been demonstrated. Such a deficit in response suppression might underlie the apparent inhibitory deficit suggested by the symptoms of OCD. To date, little direct evidence of such a deficit has been reported. Further, although OCD commonly emerges during childhood or adolescence, few studies have examined psychotropic-naive pediatric patients near the onset of illness to find the possible role of atypical developmental processes in this disorder. METHODS: Oculomotor tests were administered to 18 psychotropic medication-naive, nondepressed patients with OCD aged 8.8 to 16.9 years and 18 case-matched healthy comparison subjects to assess the following 3 well-delineated aspects of prefrontal cortical function: the ability to suppress responses, the volitional execution of delayed responses, and the anticipation of predictable events. RESULTS: A significantly higher percentage of response suppression failures was observed in patients with OCD (P = .003), particularly in younger patients compared with their case-matched controls. No significant differences between patients with OCD and controls were observed on other prefrontal cortical functions. Severity of OCD symptoms was related to response suppression deficits. CONCLUSIONS: A basic disturbance of behavioral inhibition in OCD was detected that may underlie the repetitive symptomatic behavior that characterizes the illness.
D R Rosenberg; D H Averbach; K M O'Hearn; A B Seymour; B Birmaher; J A Sweeney
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Archives of general psychiatry     Volume:  54     ISSN:  0003-990X     ISO Abbreviation:  Arch. Gen. Psychiatry     Publication Date:  1997 Sep 
Date Detail:
Created Date:  1997-09-24     Completed Date:  1997-09-24     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0372435     Medline TA:  Arch Gen Psychiatry     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  831-8     Citation Subset:  AIM; IM    
Department of Psychiatry, University of Pittsburgh Medical Center, Pa., USA.
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MeSH Terms
Age Factors
Corpus Striatum / physiology
Eye Movements / physiology*
Functional Laterality / physiology
Neural Pathways / physiology
Neuropsychological Tests
Obsessive-Compulsive Disorder / diagnosis*,  physiopathology
Personality Inventory
Prefrontal Cortex / physiology*
Psychiatric Status Rating Scales
Reaction Time / physiology
Saccades / physiology
Severity of Illness Index
Grant Support
MH-01372/MH/NIMH NIH HHS; P50-45156//PHS HHS; R01-42969//PHS HHS
Comment In:
Arch Gen Psychiatry. 1997 Sep;54(9):785-9   [PMID:  9294368 ]

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