Document Detail


Ocular toxicity following topical application of anesthetic cream to the eyelid skin.
MedLine Citation:
PMID:  8860604     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND AND OBJECTIVE: The use of topical anesthetic cream in the periorbital region may be of clinical value. The potential for toxic effects from such use has not been studied in a controlled manner. This study was performed to evaluate the potential ocular toxicity of anesthetic cream topically applied to the eyelid in an animal model. MATERIALS AND METHODS: Ten rabbits underwent periorbital eutectic mixture of local anesthetics (EMLA) (2.5 percent lidocaine and 2.5 percent prilocaine) application and were observed for evidence of gross or microscopic ocular toxicity. Baseline external and anterior segment examinations were performed, including biomicroscopy and fluorescein staining, after which a standard quantity of EMLA cream (0.75 g) was applied along the upper eyelid and covered with an occlusive dressing. After 1 hour of treatment, the eyelid and anterior segment were examined for evidence of adverse reaction. The eyelids were excised and examined histopathologically. RESULTS: No significant adverse effects were noted on external lid and anterior segment examination. The histopathologic findings were within normal limits. CONCLUSIONS: This study suggests that external application of EMLA cream to the eyelid does not induce local toxicity in the rabbit model. The external application of EMLA cream may be safe in the periorbital region.
Authors:
R G Cohen; M Hartstein; M Lahav; J J Woog; M Ladav
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Ophthalmic surgery and lasers     Volume:  27     ISSN:  1082-3069     ISO Abbreviation:  Ophthalmic Surg Lasers     Publication Date:  1996 May 
Date Detail:
Created Date:  1997-05-19     Completed Date:  1997-05-19     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  9517132     Medline TA:  Ophthalmic Surg Lasers     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  374-7     Citation Subset:  IM    
Affiliation:
New England Eye Center, Tufts University School of Medicine, Boston, MA, USA.
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MeSH Terms
Descriptor/Qualifier:
Administration, Topical
Anesthetics, Local / administration & dosage,  toxicity*
Animals
Anterior Eye Segment / drug effects*,  pathology
Drug Combinations
Drug Evaluation, Preclinical / methods
Eyelids / drug effects*,  pathology
Lidocaine / administration & dosage,  toxicity*
Ointments / administration & dosage,  toxicity*
Prilocaine / administration & dosage,  toxicity*
Rabbits
Safety
Chemical
Reg. No./Substance:
0/Anesthetics, Local; 0/Drug Combinations; 0/EMLA; 0/Ointments; 137-58-6/Lidocaine; 721-50-6/Prilocaine
Comments/Corrections
Erratum In:
Ophthalmic Surg Lasers 1996 Jul;27(7):594
Note: Ladav M [corrected to Lahav M]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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