| Ocular toxicity due to 4-aminoquinoline derivatives | |
| | |
MedLine Citation:
|
PMID: 18235926 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Retinal toxicity of chloroquine has been extensively studied since its first description in 1957. This drug is used on a chronic basis to treat several rheumatologic and dermatologic diseases, a there is a trend to use hydroxychloroquine rather than chloroquine. The recommended dose for hydroxychloroquine is 4 mg/kg lean body weight per day. The clinical picture of chloroquine retinopathy is characterized by a paracentral visual field scotoma with associated parafoveal retinal pigment epithelium atrophy, known as 'bull's eye maculopathy. The visual field and Amsler grids are the exams that early detect toxicity retinopathy. The authors aim to review the pathogenesis, clinical features, differential diagnosis, complementary exams, and treatment. The sources of references were PubMed (MEDLINE), LILACS and Ophthalmology Library databases. |
| | |
Authors:
|
Enéias Bezerra Gouveia; Maira Saad de Avila Morales; Gedeão Bezerra Gouveia; Valeria Pinheiro M Lourenzi |
Publication Detail:
|
Type: English Abstract; Journal Article; Review |
Journal Detail:
|
Title: Arquivos brasileiros de oftalmologia Volume: 70 ISSN: 0004-2749 ISO Abbreviation: Arq Bras Oftalmol Publication Date: 2007 Nov-Dec |
Date Detail:
|
Created Date: 2008-01-31 Completed Date: 2008-08-18 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0400645 Medline TA: Arq Bras Oftalmol Country: Brazil |
Other Details:
|
Languages: por Pagination: 1046-51 Citation Subset: IM |
Affiliation:
|
Centro Médico INTERSAUDE. ebgouveia@uol.com.br |
Vernacular Title:
|
Toxicidade ocular por derivados da 4-aminoquinolona. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aminoquinolines
/
adverse effects* Antimalarials / adverse effects* Corneal Diseases / chemically induced* Diagnosis, Differential Humans Hydroxychloroquine / adverse effects Macular Degeneration / diagnosis Retinal Diseases / chemically induced* |
| Chemical | |
Reg. No./Substance:
|
0/Aminoquinolines; 0/Antimalarials; 118-42-3/Hydroxychloroquine; 578-68-7/4-aminoquinoline |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Flecked retina in systemic large-cell non-Hodgkin's lymphoma: case report.
Next Document: Randomized trial of total fundoplication and fundal mobilization with or without division of short g...