| Ocular surface disease in patients with ocular hypertension and glaucoma. | |
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MedLine Citation:
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PMID: 21501071 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Purpose: To review the prevalence, diagnosis, causes, and treatment of ocular surface disease (OSD) in patients with ocular hypertension or primary open-angle glaucoma. Methods: A review of the literature pertaining to OSD and glaucoma. Results: Recent studies indicate that OSD demonstrates an overall prevalence in glaucoma of 42% (range 20-59%) and is severe in 36% (range 14-66%). Further, the prevalence appears to increase with the greater the number of glaucoma drugs prescribed. Symptoms and signs are non-specific to the anterior surface of the eye and are thought to result from allergic, toxic, or pro-inflammatory conditions. However, the specific causes remain incompletely described, but may result from the benzalkonium chloride (BAK) preservative or occasionally the ocular hypotensive active molecule itself. Additionally, anterior segment ocular diseases might be causative, such as allergy, blepharitis, dry eye, and eyelid anatomical abnormalities. Treatment may consist of using preservative-free or non-BAK preserved glaucoma medications. Also, although unproven specifically in glaucoma patients, treatment of associated diseases of the anterior surface might reduce signs and symptoms. Conclusions: OSD is common in treated glaucoma patients causing symptoms and signs that may impact on a patient's quality of life. Treatment is directed towards any underlying disease process and the use of preservative-free or non-BAK-preserved glaucoma preparations. |
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Authors:
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William C Stewart; Jeanette A Stewart; Lindsay A Nelson |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Current eye research Volume: 36 ISSN: 1460-2202 ISO Abbreviation: Curr. Eye Res. Publication Date: 2011 May |
Date Detail:
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Created Date: 2011-04-19 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8104312 Medline TA: Curr Eye Res Country: England |
Other Details:
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Languages: eng Pagination: 391-8 Citation Subset: IM |
Affiliation:
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PRN Pharmaceutical Research Network, LLC, Charleston, South Carolina, USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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