Document Detail

Ocular perfusion pressure and the incidence of glaucoma: real effect or artifact? The Rotterdam Study.
MedLine Citation:
PMID:  21715354     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To determine the association between the ocular perfusion pressure (OPP; essentially the difference between the blood pressure and the intraocular pressure [IOP]) and incident open-angle glaucoma (OAG).
METHODS: A subset of 3882 participants of the population-based Rotterdam Study for whom data from ophthalmic examinations at baseline and follow-up and blood pressure measurements at baseline were available, and who did not have OAG at baseline, were included. Associations between the mean, systolic and diastolic OPP, and incident OAG were assessed using Cox regression models adjusted for age and sex, with and without adjustment for IOP.
RESULTS: During a mean follow-up of 9.8 years, 103 participants (2.7%) developed OAG. The association between the mean OPP and incident OAG was not significant (hazard ratio 0.995 per mm Hg increase in mean OPP; 95% confidence interval 0.971-1.019) when adjusted for IOP, but became significant if not adjusted for IOP (0.968; 0.945-0.992). The systolic and diastolic OPP showed a pattern similar to that of the mean OPP, though less significant.
CONCLUSIONS: The OPP appears to be associated with incident OAG but this association seems to be due to the fact that the IOP, a strong risk factor for OAG, is part of the OPP, rather than that OPP is an independent OAG risk factor itself.
Wishal D Ramdas; Roger C W Wolfs; Albert Hofman; Paulus T V M de Jong; Johannes R Vingerling; Nomdo M Jansonius
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2011-08-29
Journal Detail:
Title:  Investigative ophthalmology & visual science     Volume:  52     ISSN:  1552-5783     ISO Abbreviation:  Invest. Ophthalmol. Vis. Sci.     Publication Date:  2011 Aug 
Date Detail:
Created Date:  2011-08-30     Completed Date:  2011-11-01     Revised Date:  2013-01-09    
Medline Journal Info:
Nlm Unique ID:  7703701     Medline TA:  Invest Ophthalmol Vis Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  6875-81     Citation Subset:  IM    
Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands.
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MeSH Terms
Age Factors
Blood Pressure / physiology
Confidence Intervals
Disease Progression
Follow-Up Studies
Glaucoma, Open-Angle / epidemiology,  physiopathology*
Intraocular Pressure / physiology*
Netherlands / epidemiology
Proportional Hazards Models
Risk Factors
Sex Factors
Tonometry, Ocular / standards*

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