| Ocular perfusion and age-related macular degeneration. | |
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MedLine Citation:
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PMID: 11284745 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To review the role of ocular perfusion in the pathophysiology of age-related macular degeneration (AMD), the leading cause of irreversible blindness in the industrialized world. METHODS: Medline search of the literature published in English or with English abstracts from 1966 to 2000 was performed using various combinations of relevant key words. RESULTS: Vascular defects have been identified in both nonexudative and exudative AMD patients using fluorescein angiographic methods, laser Doppler flowmetry, indocyanine green angiography, and color Doppler imaging. CONCLUSION: Although these studies lend some support to the vascular pathogenesis of AMD, it is not possible to determine if the choroidal perfusion abnormalities play a causative role in nonexudative AMD, if they are simply an association with another primary alteration, such as a primary RPE defect or a genetic defect at the photoreceptor level, or if they are more strongly associated with one particular form of this heterogeneous disease. Further study is warranted. |
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Authors:
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T A Ciulla; A Harris; B J Martin |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review |
Journal Detail:
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Title: Acta ophthalmologica Scandinavica Volume: 79 ISSN: 1395-3907 ISO Abbreviation: Acta Ophthalmol Scand Publication Date: 2001 Apr |
Date Detail:
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Created Date: 2001-04-04 Completed Date: 2001-05-24 Revised Date: 2008-03-17 |
Medline Journal Info:
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Nlm Unique ID: 9507578 Medline TA: Acta Ophthalmol Scand Country: Denmark |
Other Details:
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Languages: eng Pagination: 108-15 Citation Subset: IM |
Affiliation:
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Indiana University School of Medicine, Indianapolis, Indiana, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Blood Flow Velocity Choroid / blood supply Eye / blood supply* Fluorescein Angiography Humans Macular Degeneration / etiology, physiopathology* Perfusion Retinal Vessels / physiopathology |
| Grant Support | |
ID/Acronym/Agency:
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EY10801/EY/NEI NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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