| Ocular motor indicators of executive dysfunction in fragile X and Turner syndromes. | |
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MedLine Citation:
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PMID: 17107741 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Fragile X and Turner syndromes are two X-chromosome-related disorders associated with executive function and visual spatial deficits. In the present study, we used ocular motor paradigms to examine evidence that disruption to different neurological pathways underlies these deficits. We tested 17 females with fragile X, 19 females with Turner syndrome, and 40 females with neither disorder who comprised the comparison group. Group differences emerged for both the fragile X and Turner syndrome groups, each relative to the comparison group: Females with fragile X had deficits in generating memory-guided saccades, predictive saccades, and saccades made in the overlap condition of a gap/overlap task. Females with Turner syndrome showed deficits in generating memory-guided saccades, but not during either the predictive saccade or gap/overlap task. Females with Turner syndrome, but not females with fragile X, showed deficits in visually guided saccades and anti-saccades. These findings indicate that different brain regions are affected in the two disorders, and suggest that different pathways lead to the similar cognitive phenotypes described for fragile X and Turner syndromes. |
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Authors:
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Adrian G Lasker; Michèle M M Mazzocco; David S Zee |
Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, N.I.H., Extramural Date: 2006-11-14 |
Journal Detail:
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Title: Brain and cognition Volume: 63 ISSN: 0278-2626 ISO Abbreviation: Brain Cogn Publication Date: 2007 Apr |
Date Detail:
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Created Date: 2007-03-13 Completed Date: 2007-05-10 Revised Date: 2007-12-03 |
Medline Journal Info:
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Nlm Unique ID: 8218014 Medline TA: Brain Cogn Country: United States |
Other Details:
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Languages: eng Pagination: 203-20 Citation Subset: IM |
Affiliation:
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Department of Neurology, Suite 2210, Pathology Building, The Johns Hopkins School of Medicine, 601 N. Broadway, Baltimore, MD 21287-6921, USA. alasker@dizzy.med.jhu.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Analysis of Variance Child Cognition Disorders / complications, diagnosis* Eye Movement Measurements Female Fragile X Syndrome / complications*, physiopathology Humans Oculomotor Muscles / physiology, physiopathology Perceptual Disorders / complications, diagnosis* Reaction Time / physiology Reference Values Saccades / physiology* Space Perception / physiology Statistics, Nonparametric Turner Syndrome / complications*, physiopathology |
| Grant Support | |
ID/Acronym/Agency:
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NS 35356/NS/NINDS NIH HHS; R01 HD 34061/HD/NICHD NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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