| Ocular motor and imaging abnormalities of midbrain dysfunction in osmotic demyelination syndrome. | |
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MedLine Citation:
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PMID: 19952903 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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After rapid correction of severe hyponatremia, a 36-year-old man developed osmotic demyelination syndrome (ODS), manifested neurologically by impaired cognition, extremity weakness, bilateral third cranial nerve palsies, and gaze-evoked upbeat and rotary nystagmus. Brain MRI showed restricted diffusion in the rostral midbrain and temporal and parietal lobes but not in the pons. Over several weeks, all neurologic and imaging deficits resolved. This is the first report to document ocular motor abnormalities associated with midbrain dysfunction in ODS. |
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Authors:
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Kristen M Hawthorne; Christopher J Compton; Michael S Vaphiades; Glenn H Roberson; Lanning B Kline |
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Publication Detail:
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Type: Case Reports; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society Volume: 29 ISSN: 1536-5166 ISO Abbreviation: J Neuroophthalmol Publication Date: 2009 Dec |
Date Detail:
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Created Date: 2009-12-02 Completed Date: 2010-02-02 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9431308 Medline TA: J Neuroophthalmol Country: United States |
Other Details:
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Languages: eng Pagination: 296-9 Citation Subset: IM |
Affiliation:
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Department of Ophthalmology, University of Alabama School of Medicine, Birmingham, Alabama, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Blepharoptosis / complications, physiopathology Cognition Disorders / complications, physiopathology Electrolytes / adverse effects Humans Hyponatremia / complications, drug therapy Magnetic Resonance Imaging Male Mesencephalon / physiopathology* Myelinolysis, Central Pontine / chemically induced, complications, physiopathology* Ocular Motility Disorders / complications*, physiopathology Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Electrolytes |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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