| Ocular manifestations of the antiphospholipid syndrome. | |
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MedLine Citation:
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PMID: 20693557 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Antiphospholipid syndrome (APS) is an autoimmune disease characterised by a heterogenous group of antibodies directed against negatively charged phospholipids including antiphospholipid antibodies (aPL), anticardiolipin antibodies (aCL) and β-2 glycoprotein I (aβ-2-GP1). The major features of this disorder include arterial and venous thrombosis and recurrent fetal loss. The vasculature of the eye is frequently involved and may be the presenting manifestation. A diagnosis of APS should be considered in a young patients without traditional thromboembolic risk factors presenting with ocular vaso-occlusive disease. Management of these patients involves a team-approach with a haematologist/oncologist or rheumatologist to manage the coagulation status of these patients to prevent further systemic vascular occlusions. |
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Authors:
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Virginia Miraldi Utz; Johnny Tang |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Review Date: 2010-08-07 |
Journal Detail:
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Title: The British journal of ophthalmology Volume: 95 ISSN: 1468-2079 ISO Abbreviation: Br J Ophthalmol Publication Date: 2011 Apr |
Date Detail:
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Created Date: 2011-03-18 Completed Date: 2011-05-31 Revised Date: 2011-08-12 |
Medline Journal Info:
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Nlm Unique ID: 0421041 Medline TA: Br J Ophthalmol Country: England |
Other Details:
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Languages: eng Pagination: 454-9 Citation Subset: IM |
Affiliation:
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Department of Ophthalmology and Visual Sciences, Case Western Reserve University and University Hospitals Eye Institute, Cleveland, OH, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Antibodies, Antiphospholipid
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immunology Antiphospholipid Syndrome / complications*, diagnosis, immunology, physiopathology Eye Diseases / drug therapy, etiology* Hemostasis / physiology Humans Venous Thrombosis / diagnosis, drug therapy, etiology*, immunology |
| Chemical | |
Reg. No./Substance:
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0/Antibodies, Antiphospholipid |
| Comments/Corrections | |
Republished in:
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Postgrad Med J. 2011 Jul;87(1029):496-501
[PMID:
21705776
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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