Document Detail

Ocular manifestation of polychlorinated biphenyls intoxication.
MedLine Citation:
PMID:  6425847     Owner:  NLM     Status:  MEDLINE    
One hundred thirty patients with polychlorinated biphenyl (PCB) poisoning (46 males, 84 females) were examined in the department of Ophthalmology, Veterans General Hospital, Taiwan. The main ocular manifestations were profuse discharge from the eye, swelling and pigmentation of the upper lids, abnormal pigmentation of the conjunctivae, and hypersecretion and swelling of the Meibomian glands. Eye discharge was present in 104 (80.5%) of the 130 patients; swelling of upper lids was seen in 79 (60.4%); pigmentation of conjunctivae was found in 88 (67.6%); hypersecretion and cystic swelling of the Meibomian glands was seen in 92 (70.7%); and 5 patients (3.8%) required incision and drainage because of cystic formation with secondary infection of the Meibomian glands. PCB concentration in the blood was classified into five groups: 0-15 ppb, 16-40 ppb, 41-60 ppb, and over 100 ppb by gas chromatography. Positive clinical findings increased parallel to high blood PCB concentration. In particular, heavy pigmentation of conjunctivae, abnormal cystic formation and hypersecretion of the Meibomian glands occurred markedly in those patients whose blood PCB concentration was above 41 ppb. It is concluded that the severity of ocular manifestations was closely related to high blood PCB levels. Ocular signs might help not only as a guide to early diagnosis but might also serve to indicate the degree of poisoning by PCB.
Y A Fu
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Progress in clinical and biological research     Volume:  137     ISSN:  0361-7742     ISO Abbreviation:  Prog. Clin. Biol. Res.     Publication Date:  1984  
Date Detail:
Created Date:  1984-06-18     Completed Date:  1984-06-18     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  7605701     Medline TA:  Prog Clin Biol Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  127-32     Citation Subset:  IM    
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MeSH Terms
Conjunctival Diseases / chemically induced
Edema / chemically induced
Eye / secretion
Eye Diseases / chemically induced*,  pathology
Eyelid Diseases / etiology
Food Contamination*
Foodborne Diseases / etiology*
Meibomian Glands / pathology
Middle Aged
Oils / poisoning*
Pigmentation Disorders / chemically induced
Polychlorinated Biphenyls / blood,  poisoning*
Reg. No./Substance:
0/Oils; 0/Polychlorinated Biphenyls

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