Document Detail

Ocular hemorrhage possibly the result of HMG-CoA reductase inhibitors.
MedLine Citation:
PMID:  15117574     Owner:  NLM     Status:  MEDLINE    
This retrospective case series describes the association between ocular hemorrhage and 3-hydroxy-3-methylglutaryl conenzyme A (HMG-CoA) reductase inhibitors (statins). The clinical characteristics of 95 case reports submitted to the World Health Organization (WHO), the Food and Drug Administration, and the National Registry of Drug-Induced Ocular Side Effects are summarized with classification of this ocular side effect according to WHO criteria. The average time to onset of ocular hemorrhage was 300 days with 11 positive dechallenge reports and 2 positive rechallenge cases. Some patients also received medications known to increase bleeding times. From the collected data, ocular hemorrhage is "possibly" due to statin therapy.
F W Fraunfelder
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics     Volume:  20     ISSN:  1080-7683     ISO Abbreviation:  J Ocul Pharmacol Ther     Publication Date:  2004 Apr 
Date Detail:
Created Date:  2004-04-30     Completed Date:  2004-10-25     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  9511091     Medline TA:  J Ocul Pharmacol Ther     Country:  United States    
Other Details:
Languages:  eng     Pagination:  179-82     Citation Subset:  IM    
Casey Eye Institute, Oregon Health & Science University, Portland, OR 97201, USA.
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MeSH Terms
Adverse Drug Reaction Reporting Systems*
Eye Hemorrhage / chemically induced*
Hydroxymethylglutaryl-CoA Reductase Inhibitors / adverse effects*
Middle Aged
Reg. No./Substance:
0/Hydroxymethylglutaryl-CoA Reductase Inhibitors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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