| Ocular hemorrhage possibly the result of HMG-CoA reductase inhibitors. | |
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MedLine Citation:
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PMID: 15117574 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This retrospective case series describes the association between ocular hemorrhage and 3-hydroxy-3-methylglutaryl conenzyme A (HMG-CoA) reductase inhibitors (statins). The clinical characteristics of 95 case reports submitted to the World Health Organization (WHO), the Food and Drug Administration, and the National Registry of Drug-Induced Ocular Side Effects are summarized with classification of this ocular side effect according to WHO criteria. The average time to onset of ocular hemorrhage was 300 days with 11 positive dechallenge reports and 2 positive rechallenge cases. Some patients also received medications known to increase bleeding times. From the collected data, ocular hemorrhage is "possibly" due to statin therapy. |
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Authors:
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F W Fraunfelder |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics Volume: 20 ISSN: 1080-7683 ISO Abbreviation: J Ocul Pharmacol Ther Publication Date: 2004 Apr |
Date Detail:
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Created Date: 2004-04-30 Completed Date: 2004-10-25 Revised Date: 2005-11-16 |
Medline Journal Info:
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Nlm Unique ID: 9511091 Medline TA: J Ocul Pharmacol Ther Country: United States |
Other Details:
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Languages: eng Pagination: 179-82 Citation Subset: IM |
Affiliation:
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Casey Eye Institute, Oregon Health & Science University, Portland, OR 97201, USA. eyedrug@ohsu.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adverse Drug Reaction Reporting Systems* Eye Hemorrhage / chemically induced* Female Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors / adverse effects* Male Middle Aged |
| Chemical | |
Reg. No./Substance:
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0/Hydroxymethylglutaryl-CoA Reductase Inhibitors |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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