Document Detail

Ocular hemodynamic effects of acute ethanol ingestion.
MedLine Citation:
PMID:  8829177     Owner:  NLM     Status:  MEDLINE    
PURPOSE: Because the protean biological effects of ethanol include acute alterations in both cortical function and circulatory control, we investigated the effect of acute alcohol consumption on retrobulbar hemodynamics and contrast sensitivity in healthy human volunteers. SUBJECTS AND METHODS: Twelve young adults received orange juice with and without ethanol in a double-masked fashion. The ethanol dose was sufficient to raise blood alcohol to 0.07 +/- 0.003 g/dl. Retrobulbar hemodynamics were assessed at baseline and twice at elevated blood alcohol by color Doppler imaging. RESULTS: Acute elevation of blood alcohol lowered intraocular pressure from 13.0 +/- 0.7 to 10.7 +/- 0.7 mm Hg (p < 0.05). In contrast, elevated blood alcohol left peak systolic velocity, end-diastolic velocity and the resistance index constant in three retrobulbar arteries (ophthalmic, central retinal and posterior ciliary). For example, in the central retinal artery, peak systolic velocity, end-diastolic velocity and the resistance index averaged 11.0 +/- 1.3 cm/s, 2.8 +/- 0.4 cm/s and 0.75 +/- 0.03 before ethanol, as compared with 10.5 +/- 1.0 cm/s, 2.9 +/- 0.3 cm/s and 0.72 +/- 0.03 after ethanol (all p = NS). Alcohol ingestion also failed to alter either visual acuity or contrast sensitivity, as assessed under both photopic and mesopic conditions. CONCLUSIONS: Although ethanol has widespread cognitive and cardiovascular effects, at blood levels near legal definitions of intoxication we found it ineffective in altering either retrobulbar hemodynamics or contrast sensitivity.
A Harris; D Swartz; D Engen; D Beck; D Evans; K Caldemeyer; B Martin
Related Documents :
7846197 - Effect of smoking cessation and relapse on cardiovascular levels and reactivity.
2665127 - Disease states in which blood pressure is lowered.
3350237 - Reversibility of acute alcohol cardiac depression: 31p nmr in hamsters.
15588627 - Interaction between 1,4-butanediol and ethanol on operant responding and the cardiovasc...
11445317 - Nmr diffusion of hyperpolarised 3he in aerogel: a systematic pressure study.
11055547 - Relationship between free radicals and adenosine in the mechanism of preconditioning: a...
Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Ophthalmic research     Volume:  28     ISSN:  0030-3747     ISO Abbreviation:  Ophthalmic Res.     Publication Date:  1996  
Date Detail:
Created Date:  1996-12-17     Completed Date:  1996-12-17     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0267442     Medline TA:  Ophthalmic Res     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  193-200     Citation Subset:  IM    
Department of Ophthalmology, Indiana University School of Medicine, Indianapolis, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Blood Flow Velocity / drug effects
Central Nervous System Depressants / pharmacology*
Contrast Sensitivity / drug effects
Cross-Over Studies
Ethanol / pharmacology*
Eye / blood supply,  drug effects
Intraocular Pressure
Ocular Physiological Phenomena*
Ophthalmic Artery / drug effects*,  physiology
Reference Values
Retinal Artery / drug effects*,  physiology
Single-Blind Method
Ultrasonography, Doppler, Color
Grant Support
Reg. No./Substance:
0/Central Nervous System Depressants; 64-17-5/Ethanol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Preventive effect of natural and synthetic antioxidants on lipid peroxidation in the mammalian eye.
Next Document:  Cat pancreatic neurons: morphology, electrophysiological properties, and responses to 5-HT.