| Ocular hemodynamic effects of acute ethanol ingestion. | |
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MedLine Citation:
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PMID: 8829177 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: Because the protean biological effects of ethanol include acute alterations in both cortical function and circulatory control, we investigated the effect of acute alcohol consumption on retrobulbar hemodynamics and contrast sensitivity in healthy human volunteers. SUBJECTS AND METHODS: Twelve young adults received orange juice with and without ethanol in a double-masked fashion. The ethanol dose was sufficient to raise blood alcohol to 0.07 +/- 0.003 g/dl. Retrobulbar hemodynamics were assessed at baseline and twice at elevated blood alcohol by color Doppler imaging. RESULTS: Acute elevation of blood alcohol lowered intraocular pressure from 13.0 +/- 0.7 to 10.7 +/- 0.7 mm Hg (p < 0.05). In contrast, elevated blood alcohol left peak systolic velocity, end-diastolic velocity and the resistance index constant in three retrobulbar arteries (ophthalmic, central retinal and posterior ciliary). For example, in the central retinal artery, peak systolic velocity, end-diastolic velocity and the resistance index averaged 11.0 +/- 1.3 cm/s, 2.8 +/- 0.4 cm/s and 0.75 +/- 0.03 before ethanol, as compared with 10.5 +/- 1.0 cm/s, 2.9 +/- 0.3 cm/s and 0.72 +/- 0.03 after ethanol (all p = NS). Alcohol ingestion also failed to alter either visual acuity or contrast sensitivity, as assessed under both photopic and mesopic conditions. CONCLUSIONS: Although ethanol has widespread cognitive and cardiovascular effects, at blood levels near legal definitions of intoxication we found it ineffective in altering either retrobulbar hemodynamics or contrast sensitivity. |
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Authors:
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A Harris; D Swartz; D Engen; D Beck; D Evans; K Caldemeyer; B Martin |
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Publication Detail:
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Type: Clinical Trial; Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Ophthalmic research Volume: 28 ISSN: 0030-3747 ISO Abbreviation: Ophthalmic Res. Publication Date: 1996 |
Date Detail:
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Created Date: 1996-12-17 Completed Date: 1996-12-17 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 0267442 Medline TA: Ophthalmic Res Country: SWITZERLAND |
Other Details:
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Languages: eng Pagination: 193-200 Citation Subset: IM |
Affiliation:
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Department of Ophthalmology, Indiana University School of Medicine, Indianapolis, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Blood Flow Velocity / drug effects Central Nervous System Depressants / pharmacology* Contrast Sensitivity / drug effects Cross-Over Studies Ethanol / pharmacology* Eye / blood supply, drug effects Humans Intraocular Pressure Ocular Physiological Phenomena* Ophthalmic Artery / drug effects*, physiology Reference Values Retinal Artery / drug effects*, physiology Single-Blind Method Ultrasonography, Doppler, Color |
| Grant Support | |
ID/Acronym/Agency:
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EY 10801/EY/NEI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Central Nervous System Depressants; 64-17-5/Ethanol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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