Document Detail

Ocular growth and refractive error development in premature infants without retinopathy of prematurity.
MedLine Citation:
PMID:  12601014     Owner:  NLM     Status:  MEDLINE    
PURPOSE: This investigation studied the factors involved in the development of refractive error (RE) in premature infants unaffected by retinopathy of prematurity (ROP). METHODS: Premature infants enrolled in the national ROP screening program were recruited and examined at 32, 36, 40, 44, and 52 weeks' postmenstrual age. At each examination, axial length (AXL), anterior chamber depth (ACD), and lens thickness (LT) were measured on the A-scan biometer. Corneal curvature (CC) was recorded with a video-ophthalmophakometer, and refractive state was determined with routine cycloplegic refraction. Multilevel modeling techniques were used to determine the relationships between all the variables throughout the study period, as well as individual growth rates. RESULTS: Sixty-eight premature infants were included. AXL and ACD showed linear patterns of growth, whereas LT changed little over the study period. CC showed a quadratic growth pattern, and unlike the previous variables, correlated well with refractive state. Premature infants were myopes at the start of the study, with refraction becoming emmetropic as they neared full term and then hypermetropic toward the end of the study. CONCLUSIONS: Most of the components of refractive status showed linear patterns of growth during this early phase of ocular development. CC displayed a more complex pattern of growth, which correlated well with refractive state. Compared with full-term infants examined around term, this group has shorter AXLs, shallower anterior chambers, and more highly curved corneas. In addition, less of the expected hypermetropia developed in the premature group, which seems mainly due to the differences in ACD and corneal curvature.
Anne Cook; Sarah White; Mark Batterbury; David Clark
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Investigative ophthalmology & visual science     Volume:  44     ISSN:  0146-0404     ISO Abbreviation:  Invest. Ophthalmol. Vis. Sci.     Publication Date:  2003 Mar 
Date Detail:
Created Date:  2003-02-25     Completed Date:  2003-03-10     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7703701     Medline TA:  Invest Ophthalmol Vis Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  953-60     Citation Subset:  IM    
Manchester Royal Eye Hospital, Manchester, United Kingdom.
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MeSH Terms
Anterior Chamber / anatomy & histology
Birth Weight
Cornea / anatomy & histology
Eye / growth & development*,  physiopathology
Gestational Age
Infant, Newborn
Infant, Premature*
Infant, Very Low Birth Weight
Refraction, Ocular
Refractive Errors / etiology*,  physiopathology
Retinopathy of Prematurity / complications

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