| Ocular and generalized myasthenia gravis induced by human acetylcholine receptor γ subunit immunization. | |
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MedLine Citation:
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PMID: 22246876 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Introduction: HLA-DQ8 transgenic mice develop ocular myasthenia gravis (oMG), which then progresses to generalized MG (gMG) when immunized with the human acetylcholine receptor (H-AChR) α subunit. Because the fetal AChR γ subunit is expressed in adult extraocular muscles, we anticipated that γ subunit immunization would generate an immune response to mouse AChR and induce MG in mice. Results: H-AChR γ subunit immunization in HLA-DQ8 mice induced an autoimmune response to mouse AChR and led to the destruction of AChR in the neuromuscular junction (NMJ) by anti-AChR antibody and complement activation, and it triggered upregulation of AChR gene transcription. Conclusion: Our findings indicate that oMG may be induced by immunity to the AChR γ subunit. Muscle Nerve, 2012. |
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Authors:
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Xiaorong Wu; Erdem Tuzun; Jing Li; Tianlin Xiao; Shamsher S Saini; Huibin Qi; Windy Allman; Premkumar Christadoss |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Muscle & nerve Volume: 45 ISSN: 1097-4598 ISO Abbreviation: Muscle Nerve Publication Date: 2012 Feb |
Date Detail:
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Created Date: 2012-01-16 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7803146 Medline TA: Muscle Nerve Country: United States |
Other Details:
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Languages: eng Pagination: 209-16 Citation Subset: IM |
Copyright Information:
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Copyright © 2011 Wiley Periodicals, Inc. |
Affiliation:
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Department of Ophthalmology, Second Xiangya Hospital, Central South University, Changsha, China. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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