Document Detail

Ocular findings in sickle cell patients on Curaçao.
MedLine Citation:
PMID:  2010268     Owner:  NLM     Status:  MEDLINE    
We examined about half the estimated number (based on gene frequency) of sickle cell patients on the island of Curaçao. This study may represent one of the most comprehensive and a selective cross-sectional surveys available. Studying 81 Hb SS and 97 Hb SC patients, we were able to confirm the correlation between iris atrophy and proliferative sickle retinopathy (PSR), the correlation between Hb SC and proliferative sickle retinopathy (PSR) and the major role of PSR in blindness in sickle cell patients. In Hb SC patients over the age of 18 PSR occurred in 50%, leading to vitreous hemorrhage in 18% and to retinal detachment in 8%. We found a frequency of blindness in one eye (fingers counting or less) of 4% in the entire sickle population, and 6% among Hb SC patients. Bilateral blindness was rare: one Hb SS patient, due to cortical blindness. The relatively frequent occurrence of severe complications in a narrowly defined population should stimulate our efforts to prevent these from occurring.
J C van Meurs
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International ophthalmology     Volume:  15     ISSN:  0165-5701     ISO Abbreviation:  Int Ophthalmol     Publication Date:  1991 Jan 
Date Detail:
Created Date:  1991-05-08     Completed Date:  1991-05-08     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7904294     Medline TA:  Int Ophthalmol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  53-9     Citation Subset:  IM    
Vitreoretinal Department, Oogziekenhuis Rotterdam, The Netherlands.
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MeSH Terms
Aged, 80 and over
Anemia, Sickle Cell / complications*,  epidemiology
Blindness / etiology
Child, Preschool
Cross-Sectional Studies
Fluorescein Angiography
Fundus Oculi
Hemoglobin SC Disease / complications*,  epidemiology
Infant, Newborn
Iris Diseases / complications
Middle Aged
Netherlands Antilles / epidemiology
Retinal Detachment / complications
Retinal Diseases / complications,  diagnosis,  etiology*
Retinal Neovascularization / complications
Vitreous Hemorrhage / complications

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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