Document Detail

Ocular findings in cystic fibrosis patients receiving vitamin A supplementation.
MedLine Citation:
PMID:  8566828     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Vitamin A deficiency with eye symptoms has been reported in patients with cystic fibrosis who received the recommended daily intake of vitamin A. METHODS: We measured serum retinol, dark adaptation, contrast sensitivity, and dry eye status in 35 adult cystic fibrosis patients to ascertain whether they had ocular signs or symptoms. RESULTS: Median serum retinol concentration was 1.95 mumol/l, range 1.08-4.01 mumol/l, with no values indicating vitamin A deficiency. Retinal light sensitivity was normal. Nineteen patients had reduced contrast sensitivity. Conjunctival imprints all showed plenty of goblet cells, but were characteristic of dry eye in 42% of patients (n = 14). Decreased tear film stability was found in 49% (n = 17), tear production was low in 31% (n = 11), and 23% (n = 8) showed an increased amount of dying epithelial cells. Nine patients (26%) had keratoconjunctivitis sicca according to the Copenhagen criteria. CONCLUSION: Our patients had no biochemical or clinical signs of vitamin A deficiency. We speculate that the high incidence of dry eye could be a primary manifestation of cystic fibrosis.
J C Morkeberg; C Edmund; J U Prause; S Lanng; C Koch; K F Michaelsen
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv für klinische und experimentelle Ophthalmologie     Volume:  233     ISSN:  0721-832X     ISO Abbreviation:  Graefes Arch. Clin. Exp. Ophthalmol.     Publication Date:  1995 Nov 
Date Detail:
Created Date:  1996-03-01     Completed Date:  1996-03-01     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8205248     Medline TA:  Graefes Arch Clin Exp Ophthalmol     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  709-13     Citation Subset:  IM    
Department of Pediatrics, Cystic Fibrosis Center, State University Hospital, Copenhagen, Denmark.
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MeSH Terms
Color Vision Defects / etiology
Conjunctiva / pathology
Contrast Sensitivity
Cystic Fibrosis / blood,  complications*
Dark Adaptation
Keratoconjunctivitis Sicca / etiology*
Night Blindness / blood,  drug therapy*,  etiology
Vitamin A / blood,  therapeutic use*
Vitamin A Deficiency / blood,  drug therapy*,  etiology
Xerophthalmia / blood,  drug therapy*,  etiology
Reg. No./Substance:
11103-57-4/Vitamin A

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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