| Ocular effects in long-term amiodarone therapy. | |
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MedLine Citation:
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PMID: 6613837 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The ocular complications of long-term amiodarone therapy have been recognized for many years, but systematic data on the prognostic significance and the precise incidence of such effects have not been evaluated until recently. One hundred seventy-five patients receiving long-term amiodarone treatment have thus been followed for periods ranging from 3 months to nearly 10 years. Of 103 of these patients studied in greater depth, 98% have shown the characteristic patterns of corneal microdeposits, which progressed over several months and ultimately formed a stable appearance that changed only with an alteration of dose. The abnormalities, the nature of which is not clearly understood, disappeared within 7 months in the 16 patients whose drug was withdrawn for unrelated reasons, and no permanent ocular damage has been detected. Visual symptoms associated with the corneal deposits developed in 6% of patients: 3% had photophobia, 2% halos, and 1% blurring of vision but without impairment of visual acuity. It is concluded that ocular complications of amiodarone therapy are insignificant; they do not pose a threat to vision, and routine ophthalmologic surveillance does not appear mandatory in the majority of patients during long-term drug therapy. |
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Authors:
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D V Ingram |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: American heart journal Volume: 106 ISSN: 0002-8703 ISO Abbreviation: Am. Heart J. Publication Date: 1983 Oct |
Date Detail:
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Created Date: 1983-10-28 Completed Date: 1983-10-28 Revised Date: 2006-02-27 |
Medline Journal Info:
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Nlm Unique ID: 0370465 Medline TA: Am Heart J Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 902-5 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Amiodarone
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administration & dosage,
adverse effects*,
therapeutic use Benzofurans / adverse effects* Corneal Diseases / chemically induced, pathology Eye Diseases / chemically induced* Humans Vision Disorders / chemically induced |
| Chemical | |
Reg. No./Substance:
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0/Benzofurans; 1951-25-3/Amiodarone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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