Document Detail


Ocular effects of adrenergic stereoisomers in the rabbit.
MedLine Citation:
PMID:  3880068     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Because of the need to develop ocular hypotensive agents with low incidence of side effects, the dextrorotatory enantiomers of adrenergic agents have prompted some attention. In the present study, the relative potency and efficacy of various adrenergic stereoisomers with respect to their ocular hypotensive and mydriatic effects have been determined after topical administration to conscious rabbits. The relative order of potency was found to be, iris: 1-epinephrine much greater than d-epinephrine congruent to 1-norepinephrine congruent to dl-alpha-methyl-norepinephrine greater than dl-alpha-methyl-epinephrine greater than d-norepinephrine; intraocular pressure (IOP): l-epinephrine greater than dl-alpha-methyl-epinephrine greater than d-epinephrine greater than dl-alpha-methyl-norepinephrine greater than d-norepinephrine congruent to 1-norepinephrine. The pupil and the initial ocular hypertensive responses clearly demonstrated the phenomenon of stereoselectivity of adrenergic stimulants, in that the 1-form was relatively more potent than the d-form. However, such order of potency does not seem to hold for IOP. The apparent discrepancy and reversal of order of potency for IOP responses may be related to the hypothesis that the net ocular hypotensive effect of adrenergic agents is the summation of the initial hypertension and the delayed hypotension produced by these agents. It is anticipated that the results of the present study may improve our understanding of ocular pharmacology of adrenergic stereoisomers. The ability to separate the dose-response profiles of pupillary and IOP effects of these agents may have potential therapeutic significance and thus warrants further investigation in other species.
Authors:
T Gherezghiher; M C Koss
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of ocular pharmacology     Volume:  1     ISSN:  8756-3320     ISO Abbreviation:  J Ocul Pharmacol     Publication Date:  1985  
Date Detail:
Created Date:  1989-03-17     Completed Date:  1989-03-17     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8511297     Medline TA:  J Ocul Pharmacol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  19-28     Citation Subset:  IM    
Affiliation:
Dean A. McGee Institute, Oklahoma City.
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MeSH Terms
Descriptor/Qualifier:
Animals
Dose-Response Relationship, Drug
Epinephrine / pharmacology*
Female
Intraocular Pressure / drug effects*
Male
Norepinephrine / pharmacology*
Rabbits
Reflex, Pupillary / drug effects*
Stereoisomerism
Chemical
Reg. No./Substance:
51-41-2/Norepinephrine; 51-43-4/Epinephrine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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