Document Detail

Ocular dynamics of systemic aqueous extracts of Xylopia aethiopica (African guinea pepper) seeds on visually active volunteers.
MedLine Citation:
PMID:  12738077     Owner:  NLM     Status:  MEDLINE    
Xylopia aethiopica, African guinea pepper, is an angiosperm belonging to the family Annonecae, and used mainly as spice and in traditional medicine. The ocular dynamics of bolus consumption of 300 mg total dose was undertaken on visually active volunteers with a view to finding its ocular effects or complications. Results showed that the aqueous extract of X. aethiopica was neither a miotic nor a mydriatic, but lowered the intraocular pressure (17.48%), reduced the near point of convergence (31.1%) and increased the amplitude of accommodation (8.98%) which are positively correlated (r=0.95). On the other hand, the systemic extract had no effect on the visual acuity at far and near as well as the phoria status at the appropriate distances. The convergence excess resulted in esophoria and the increased amplitude of accommodation placed greater demand on accommodation mechanism without any discomfort. The nonspecific mechanism of action makes it a safer spice which can be exploited in the management of exophoria and raised intraocular pressure (glaucoma) in instances where the efficacy of the older conventional drugs is insufficient.
S A Igwe; J C Afonne; S I Ghasi
Related Documents :
20596717 - The diurnal variation of intraocular pressure--the most important symptom for early det...
23608627 - Chelidonium majus and its effects on uterine contractility in a perfusion model.
22833367 - Timing and efficacy of alternative methods of sympathetic blockade.
922567 - The value of pancuronium in prolonged intraocular operations.
24286407 - Evaluation of the asynchronization and function of the left ventricle in patients with ...
24495897 - A wearable and highly sensitive pressure sensor with ultrathin gold nanowires.
Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  Journal of ethnopharmacology     Volume:  86     ISSN:  0378-8741     ISO Abbreviation:  J Ethnopharmacol     Publication Date:  2003 Jun 
Date Detail:
Created Date:  2003-05-09     Completed Date:  2003-09-09     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7903310     Medline TA:  J Ethnopharmacol     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  139-42     Citation Subset:  IM    
Department of Pharmacology and Therapeutics, College of Medicine and Health Sciences, Abia State University, P.M.B. 2000, Uturu, Nigeria.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Convergence, Ocular / drug effects*
Intraocular Pressure / drug effects*
Plant Extracts / isolation & purification,  pharmacology*
Visual Acuity / drug effects*
Reg. No./Substance:
0/Plant Extracts

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Effects of Solanum melongena (garden egg) on some visual functions of visually active Igbos of Niger...
Next Document:  Ethnobotanical survey and in vitro antiplasmodial activity of plants used in traditional medicine in...