Document Detail


Ocular complications in myelodysplastic syndromes as preleukemic disorders.
MedLine Citation:
PMID:  16187037     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: To identify ocular complications in patients with myelodysplastic syndromes (MDS), who have a propensity to progress to acute myeloid leukemia (AML). METHODS: Forty-one patients with MDS were the subjects in this retrospective study, and 21 patients with AML were selected as controls. Reviewing their clinical records, we verified that corneal ulcer, iridocyclitis, vitreous hemorrhage, retinal hemorrhage, and optic neuritis had been evaluated using slit-lamp assessment and opthalmoscopy in all the patients. In this study, the MDS patients were classified into those with refractory anemia (RA) and those with refractory anemia with excess blasts (RAEB). RESULTS: Ocular complications were found in 19 (46.3%) of the 41 patients with MDS, comprising corneal ulcer (two cases), iridocyclitis (five), vitreous hemorrhage (one), retinal hemorrhage (ten), cotton wool spots (one), and optic neuritis (two). (Some patients had more than one ocular complication.) Ocular complications were identified in 12 of the 21 (57.1%) patients with AML. There was no significant difference in frequency of ocular complications between MDS and AML (P = 0.4892). In MDS, retinal hemorrhage was associated with significantly reduced platelet counts (P = 0.0063). The frequency of ocular complications was significantly higher in MDS-RAEB than in MDS-RA (P = 0.0478). Retinal hemorrhage was significantly more frequent in patients with MDS-RAEB than in patients with MDS-RA (P = 0.0433). CONCLUSION: Ocular complications in MDS patients should be carefully examined as prognostic factors for progression to acute leukemia.
Authors:
Takeshi Kezuka; Norio Usui; Etsuko Suzuki; Kazunori Wakasugi; Masahiko Usui
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Japanese journal of ophthalmology     Volume:  49     ISSN:  0021-5155     ISO Abbreviation:  Jpn. J. Ophthalmol.     Publication Date:    2005 Sep-Oct
Date Detail:
Created Date:  2005-09-27     Completed Date:  2005-10-24     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0044652     Medline TA:  Jpn J Ophthalmol     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  377-83     Citation Subset:  IM    
Affiliation:
Department of Ophthalmology, Tokyo Medical University, Tokyo, Japan. tkezuka@tokyo-med.ac.jp
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MeSH Terms
Descriptor/Qualifier:
Acute Disease
Adult
Aged
Aged, 80 and over
Disease Progression
Eye Diseases / complications*,  diagnosis,  epidemiology
Female
Humans
Leukemia, Myeloid / complications,  diagnosis,  epidemiology
Male
Middle Aged
Myelodysplastic Syndromes / complications*,  diagnosis,  epidemiology
Platelet Count
Preleukemia / complications*,  diagnosis,  epidemiology
Prevalence
Retrospective Studies

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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