Document Detail

Ocular complications at the limits of viability.
MedLine Citation:
PMID:  17407455     Owner:  NLM     Status:  MEDLINE    
AIM: To evaluate the incidence of retinopathy of prematurity (ROP) and other ocular morbidities in extremely premature infants. METHODS: A retrospective analysis of the prevalence and nature of ocular abnormalities in a cohort of 22 extremely pre-term infants born <25 + 0 weeks of estimated gestational age (GA) was performed. RESULTS: The children were grouped according to the observed disorder: 13 out of 22 (59%) neonates with mild ophthalmologic findings (ROP < or = stage II) [Group 1], 5 out of 22 (23%) infants with ROP stage III or more (Group 2) and 4 out of 22 (18%) neonates with severe ocular morbidity (congenital cataract, microphthalmia, partial optic nerve atrophy and corneal perforation due to an ulcer with lens protrusion), partly combined with ROP > or = stage III (three of four). One child of 22 (5%) needed laser therapy. Out of 22 admitted infants, 20 (91%) were discharged alive. CONCLUSION: The high rate of ocular morbidity besides ROP in extremely pre-term infants is noteworthy. Mechanisms influencing the postnatal development of the eye, especially their relation to the grade of prematurity and neonatological therapeutical strategies, require further investigations.
Ferdinand Pulzer; Eva Robel-Tillig; Matthias Knüpfer; Christian Foja; Corinna Gebauer; Wieland Kiess
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta paediatrica (Oslo, Norway : 1992)     Volume:  96     ISSN:  0803-5253     ISO Abbreviation:  Acta Paediatr.     Publication Date:  2007 Mar 
Date Detail:
Created Date:  2007-04-04     Completed Date:  2007-05-01     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9205968     Medline TA:  Acta Paediatr     Country:  Norway    
Other Details:
Languages:  eng     Pagination:  353-7     Citation Subset:  IM    
Children's Hospital, University of Leipzig, Germany.
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MeSH Terms
Eye Diseases / epidemiology*
Fetal Viability
Gestational Age
Infant, Newborn
Infant, Premature
Length of Stay
Leukomalacia, Periventricular / epidemiology
Retinopathy of Prematurity / epidemiology*
Retrospective Studies

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