| Ocular complications of Stevens-Johnson syndrome and toxic epidermal necrolysis. | |
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MedLine Citation:
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PMID: 20555046 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The causative factors and ocular complications of Stevens-Johnson syndrome and toxic epidermal necrolysis are reported here. Six out of seven patients developed the syndrome secondary to ingestion of sulphadoxine/pyrimethamine while one developed it as a complication of HAART (highly active antiretroviral therapy). The ocular complications were ankyloblepharon, symblepharon, chronic conjunctivitis, corneal vascularization and conjunctivalization, and blindness. One patient died. A shift to the WHO-recommened artemisin-based combination therapy for the treatment of malaria is advised. Early referral to the ophthalmologist will help to reduce the complications. |
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Authors:
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Catherine U Ukponmwan; Itiyafe Njinaka; Efe T Ehimiyen |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Tropical doctor Volume: 40 ISSN: 1758-1133 ISO Abbreviation: Trop Doct Publication Date: 2010 Jul |
Date Detail:
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Created Date: 2010-06-17 Completed Date: 2010-08-03 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 1301706 Medline TA: Trop Doct Country: England |
Other Details:
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Languages: eng Pagination: 167-8 Citation Subset: IM |
Affiliation:
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Department of Ophthalmology, University of Benin Teaching Hospital, PMB: 1154, Benin City, Nigeria. kateukponmwan@yahoo.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Anti-Bacterial Agents / administration & dosage Antiretroviral Therapy, Highly Active / adverse effects* Child, Preschool Epidermal Necrolysis, Toxic / complications, etiology*, therapy Eye Diseases / drug therapy, etiology* Female Hospitals, University Humans Male Nigeria Ophthalmic Solutions Stevens-Johnson Syndrome / complications*, etiology, therapy Trimethoprim-Sulfamethoxazole Combination / adverse effects* |
| Chemical | |
Reg. No./Substance:
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0/Anti-Bacterial Agents; 0/Ophthalmic Solutions; 8064-90-2/Trimethoprim-Sulfamethoxazole Combination |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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