| Ocular changes due to the treatment of juvenile systemic lupus erythematosus. | |
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MedLine Citation:
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PMID: 22124590 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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OBJECTIVE: To assess retrospectively the ocular changes in children and adolescents with juvenile systemic lupus erythematosus (JSLE) in a tertiary pediatric rheumatology service. METHODS: This study assessed 117 JSLE patients (85.5% female, 60.7% non-Caucasian), who met at least four criteria of the 1997 SLE classification of the American College of Rheumatology. Their mean age was 10.4 years, and their mean time of disease progression was 5.4 years. A protocol containing clinical and demographic data, ophthalmologic complaints and changes, age of onset, duration of medication use, and cumulative medication dose was applied. RESULTS: Of the 117 patients, 24 (20.5%) had ocular changes. Sixteen of them had abnormal fundoscopy associated with systemic hypertension and/or use of chloroquine; four had cataract; two had glaucoma; and two had cataract and glaucoma. The mean age of ocular change onset was 14.1 years. Patients with ocular changes received statistically higher and longer doses of glucocorticoid pulse therapy as compared with patients without ocular changes [1.5 (0.4 to 1.6) versus 1 (0.2 to 1.6) mg/kg, P = 0.003; 25.7 (2-99) versus 17.8 (1-114) months, P = 0.0001, respectively]. CONCLUSION: A high prevalence of ocular changes relating mainly to the treatment of JSLE was observed. This demonstrates the need for regular ophthalmologic examinations even in asymptomatic patients, aiming at the early diagnosis and intervention, and at decreasing the ocular morbidity related to that disease. |
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Authors:
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Melissa Mariti Fraga; Claudio Arnaldo Len; Luciana Peixoto Dos Santos Finamor; Kimble Teixeira Fonseca Matos; Cristina Muccioli; Maria Odete Esteves Hilário; Maria Teresa Ramos Ascensão Terreri |
Publication Detail:
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Type: JOURNAL ARTICLE |
Journal Detail:
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Title: Revista brasileira de reumatologia Volume: 51 ISSN: 1809-4570 ISO Abbreviation: - Publication Date: 2011 Dec |
Date Detail:
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Created Date: 2011-11-29 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0404256 Medline TA: Rev Bras Reumatol Country: - |
Other Details:
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Languages: ENG; POR Pagination: 554-557 Citation Subset: - |
Affiliation:
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setor de Reumatologia Pediátrica, Departamento de Pediatria, Universidade Federal de São Paulo. |
Vernacular Title:
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Alterações oftalmológicas decorrentes do tratamento do lúpus eritematoso sistêmico juvenil. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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