Document Detail


Ocular artery thrombosis as an initial presentation of a prothrombin G20210A mutation.
MedLine Citation:
PMID:  20493583     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The G20210A mutation in the prothrombin gene is an established risk factor for venous thrombosis. There is controversy as to the role played by this mutation in arterial thrombotic disease. We present the case of a 56-year-old man who presented with a central retinal artery occlusion of the left eye. Evaluation revealed hypercholesterolemia, smoking, and heterozygosity for the prothrombin G20210A mutation. The literature concerning hereditary thrombophilia and retinal artery occlusion was reviewed. The synergistic effect of multiple risk factors is emphasized. Screening for hereditary thrombophilia should be considered, regardless of patient age. The prothrombin G20210A mutation may be associated with central retinal artery occlusion.
Authors:
C Parc; E Tiberghien; V Pierre-Kahn
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Publication Detail:
Type:  Case Reports; Journal Article     Date:  2010-05-20
Journal Detail:
Title:  Journal français d'ophtalmologie     Volume:  33     ISSN:  1773-0597     ISO Abbreviation:  J Fr Ophtalmol     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-07-15     Completed Date:  2010-10-21     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7804128     Medline TA:  J Fr Ophtalmol     Country:  France    
Other Details:
Languages:  eng     Pagination:  380-2     Citation Subset:  IM    
Copyright Information:
Copyright (c) 2010 Elsevier Masson SAS. All rights reserved.
Affiliation:
Service d'ophtalmologie, hôpital Foch, 40, rue Worth, 92150 Suresnes, France. c.parc@hopital-foch.org
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MeSH Terms
Descriptor/Qualifier:
Cerebral Angiography
Fluorescein Angiography
Heterozygote
Humans
Hypercholesterolemia / complications
Male
Mass Screening
Middle Aged
Mutation / genetics*
Ophthalmoscopy
Prothrombin / genetics*
Retinal Artery Occlusion / diagnosis,  etiology*
Risk Factors
Smoking / adverse effects
Thrombophilia / diagnosis,  genetics
Chemical
Reg. No./Substance:
9001-26-7/Prothrombin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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