| Ocular artery thrombosis as an initial presentation of a prothrombin G20210A mutation. | |
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MedLine Citation:
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PMID: 20493583 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The G20210A mutation in the prothrombin gene is an established risk factor for venous thrombosis. There is controversy as to the role played by this mutation in arterial thrombotic disease. We present the case of a 56-year-old man who presented with a central retinal artery occlusion of the left eye. Evaluation revealed hypercholesterolemia, smoking, and heterozygosity for the prothrombin G20210A mutation. The literature concerning hereditary thrombophilia and retinal artery occlusion was reviewed. The synergistic effect of multiple risk factors is emphasized. Screening for hereditary thrombophilia should be considered, regardless of patient age. The prothrombin G20210A mutation may be associated with central retinal artery occlusion. |
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Authors:
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C Parc; E Tiberghien; V Pierre-Kahn |
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Publication Detail:
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Type: Case Reports; Journal Article Date: 2010-05-20 |
Journal Detail:
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Title: Journal français d'ophtalmologie Volume: 33 ISSN: 1773-0597 ISO Abbreviation: J Fr Ophtalmol Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-07-15 Completed Date: 2010-10-21 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7804128 Medline TA: J Fr Ophtalmol Country: France |
Other Details:
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Languages: eng Pagination: 380-2 Citation Subset: IM |
Copyright Information:
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Copyright (c) 2010 Elsevier Masson SAS. All rights reserved. |
Affiliation:
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Service d'ophtalmologie, hôpital Foch, 40, rue Worth, 92150 Suresnes, France. c.parc@hopital-foch.org |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Cerebral Angiography Fluorescein Angiography Heterozygote Humans Hypercholesterolemia / complications Male Mass Screening Middle Aged Mutation / genetics* Ophthalmoscopy Prothrombin / genetics* Retinal Artery Occlusion / diagnosis, etiology* Risk Factors Smoking / adverse effects Thrombophilia / diagnosis, genetics |
| Chemical | |
Reg. No./Substance:
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9001-26-7/Prothrombin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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