| Ocular adnexal mucosa-associated lymphoid tissue lymphoma with polyclonal hypergammaglobulinemia. | |
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MedLine Citation:
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PMID: 18336788 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To determine the characteristics of patients with primary ocular adnexal mucosa-associated lymphoid tissue (MALT) lymphoma associated with polyclonal hypergammaglobulinemia. DESIGN: Case series study. METHODS: Among 81 Japanese patients with primary ocular adnexal MALT lymphoma, seven patients (9%) were diagnosed with polyclonal hypergammaglobulinemia. Patient clinical data included a history of autoimmune disease and dissemination. Peripheral blood collected from all patients was analyzed for serum levels of rheumatoid factor, soluble interleukin-2 receptor (sIL-2R), and immunoglobulins at the time of diagnosis and after each treatment. RESULTS: Seven patients with polyclonal hypergammaglobulinemia had elevated serum levels of rheumatoid factor, sIL-2R, immunoglobulin G (IgG), and immunoglobulin E (IgE) at the time of diagnosis. One patient had Sjogren syndrome. Six patients (86%) had a dissemination of the MALT lymphoma or lymphadenopathy at the time of diagnosis. Histopathologic examination of the patients with lymphadenopathy revealed not only MALT lymphoma but also secondary follicles. None of the seven patients showed improvement in serum levels of IgG, rheumatoid factor, or sIL-2R in spite of complete regression of the ocular lesions after radiotherapy. After administration of cyclophosphamide/doxorubicin/vincristine/prednisone and/or rituximab to three patients, all three showed improved serum levels of IgG, rheumatoid factor, and sIL-2R. CONCLUSIONS: Patients with ocular adnexal MALT lymphoma and polyclonal hypergammaglobulinemia have elevated serum levels of rheumatoid factor, sIL-2R, and IgE, and high dissemination or lymphadenopathy. These unique characteristics may correlate with the systemic immunologic imbalances. |
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Authors:
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Toshinobu Kubota; Suzuko Moritani; Tadashi Yoshino; Hirokazu Nagai; Hiroko Terasaki |
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Publication Detail:
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Type: Journal Article Date: 2008-03-12 |
Journal Detail:
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Title: American journal of ophthalmology Volume: 145 ISSN: 0002-9394 ISO Abbreviation: Am. J. Ophthalmol. Publication Date: 2008 Jun |
Date Detail:
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Created Date: 2008-05-27 Completed Date: 2008-06-24 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0370500 Medline TA: Am J Ophthalmol Country: United States |
Other Details:
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Languages: eng Pagination: 1002-1006 Citation Subset: AIM; IM |
Affiliation:
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Department of Ophthalmology, National Hospital Organization, Nagoya Medical Center, 4-4-1 Sanno-maru, Naka-ku, Nagoya, Japan. ganiky@nnh.hosp.go.jp |
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aged, 80 and over Antineoplastic Combined Chemotherapy Protocols / therapeutic use Combined Modality Therapy Conjunctival Neoplasms / complications*, pathology, therapy Female Humans Hypergammaglobulinemia / blood, complications*, therapy Immunoglobulin G / blood Lacrimal Apparatus Diseases / complications*, pathology, therapy Lymphoma, B-Cell, Marginal Zone / complications*, pathology, therapy Male Middle Aged Orbital Neoplasms / complications*, pathology, therapy Radiotherapy Receptors, Interleukin-2 / blood Rheumatoid Factor / blood |
| Chemical | |
Reg. No./Substance:
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0/Immunoglobulin G; 0/Receptors, Interleukin-2; 9009-79-4/Rheumatoid Factor |
| Comments/Corrections | |
Comment In:
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Am J Ophthalmol. 2008 Jun;145(6):941-50
[PMID:
18405875
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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