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Ocular Surface Characteristics and Impression Cytology in Patients with Active versus Inactive Thyroid Eye Disease.
MedLine Citation:
PMID:  22678867     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
PURPOSE: To compare the clinical findings, tear film function and impression cytology between patients with active and inactive Thyroid Eye Disease (TED).
METHODS: A total of 56 patients with TED and 30 controls were recruited in this prospective observational cohort study. TED patients were divided into active TED and inactive TED types according to a seven-point modified formulation of the Clinical Activity Score (CAS). All participants underwent full eye examinations including Ocular Surface Disease Index (OSDI) score, tear film break-up time (TBUT), fluorescein staining and Schirmer I test. Thirty nine patients with thyroid-associated orbitopathy (TAO) received Nelson's grade with conjunctival impression cytology. Proptosis, palpebral fissure width and lagophthalmos were assessed.
RESULTS: Ocular surface parameters including proptosis, palpebral fissure width and lagophthalmos did not differ between active and inactive TED patients (P>0.05). Both active and inactive TED patients obtained higher fluorescein staining scores, lower TBUT scores and significantly lower Schirmer test scores than those of controls (P<0.001 for all). Additionally, the TBUT score was significantly lower and the OSDI score significantly higher in the active TED group compared with those in the inactive TED group (P<0.001 for both). Impression cytology revealed a higher proportion of grade 2-3 changes in the active TED group compared with the inactive TED group (P<0.001).
CONCLUSION: Orbital inflammation in TED patients may lead to decreased tear film stability and ocular surface squamous metaplasia.
Authors:
Nuo Xu; Dan Ping Huang; Hua Sheng Yang; Zhao Guang Lai; Quan Luo
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Yan ke xue bao = Eye science / "Yan ke xue bao" bian ji bu     Volume:  27     ISSN:  1000-4432     ISO Abbreviation:  Yan Ke Xue Bao     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-06-08     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8605666     Medline TA:  Yan Ke Xue Bao     Country:  China    
Other Details:
Languages:  eng     Pagination:  64-8     Citation Subset:  IM    
Affiliation:
1.Fujian Provincial Hospital, Fuzhou 350001, China 2.Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou 510060, China 3. People's Hospital of Guangxi Zhuang Autonomous Region,Nanning 530021,China.
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