| Octreotide scintigraphy in the detection of recurrent paragangliomas. | |
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MedLine Citation:
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PMID: 15100648 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: Conventional follow-up of surgically and radiotherapy-treated paragangliomas is usually carried out with physical examinations and either magnetic resonance imaging and/or computed tomography. Up to now, octreotide has been reserved for primary diagnosis, for which it has been shown to be a reliable imaging modality. However, the postsurgical and postradiation changes seen on conventional imaging make the diagnosis of small recurrent lesions difficult. We sought to evaluate the role of octreotide scintigraphy in the detection of recurrent paragangliomas. STUDY DESIGN: We based this case series on 3 patients who were found to have recurrent paragangliomas after primary surgical resection. All patients underwent octreotide scintigraphy during routine follow-up. RESULTS: Three patients were found to have recurrent paragangliomas using octreotide scintigraphy. In one of the patients, conventional imaging (magnetic resonance imaging, computed tomography) failed to detect the recurrence. CONCLUSION: The octreotide study was able to detect the small recurrences because octreotide binds directly to receptors on the tumor and is not affected by postsurgical or postradiotherapy changes. The intrinsic resolution of most commercially available gamma cameras is about 1 cm, making it quite sensitive to detect small tumors. Although this patient did not have synchronous lesions, octreotide scintigraphy can also aide in the detection of such lesions. |
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Authors:
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Andres Bustillo; F F Telischi |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery Volume: 130 ISSN: 0194-5998 ISO Abbreviation: Otolaryngol Head Neck Surg Publication Date: 2004 Apr |
Date Detail:
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Created Date: 2004-04-21 Completed Date: 2004-05-21 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8508176 Medline TA: Otolaryngol Head Neck Surg Country: United States |
Other Details:
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Languages: eng Pagination: 479-82 Citation Subset: IM |
Affiliation:
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Department of Otolaryngology, University of Miami School of Medicine, Miami, Florida 33136, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Female Glomus Jugulare Tumor / diagnosis, radionuclide imaging*, surgery Humans Indium Radioisotopes / diagnostic use* Magnetic Resonance Imaging Male Middle Aged Neoplasm Recurrence, Local / radionuclide imaging* Octreotide / analogs & derivatives*, diagnostic use* |
| Chemical | |
Reg. No./Substance:
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0/Indium Radioisotopes; 0/indium-111-octreotide; 83150-76-9/Octreotide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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