Document Detail

Octreotide and gastrointestinal fistulae.
MedLine Citation:
PMID:  2185968     Owner:  NLM     Status:  MEDLINE    
The place of somatostatin and its analogues in the management of gastrointestinal fistulae is reviewed, drawing attention to the difficulty of assessing treatments that influence spontaneous closure. Sixteen patients with gastric, small bowel, and pancreatic fistulae were randomized to receive octreotide injections (100 micrograms t.i.d.) or placebo for 12 days. Spontaneous fistula closure occurred in 7 at a mean of 37 days after entering the trial. A second study is underway with greater patient numbers recruited from peripheral hospitals and with an increased period of octreotide medication (21 days).
N A Scott; S Finnegan; M H Irving
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Digestion     Volume:  45 Suppl 1     ISSN:  0012-2823     ISO Abbreviation:  Digestion     Publication Date:  1990  
Date Detail:
Created Date:  1990-06-14     Completed Date:  1990-06-14     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0150472     Medline TA:  Digestion     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  66-70; discussion 70-1     Citation Subset:  IM    
University Department of Surgery, Hope Hospital, Salford, UK.
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MeSH Terms
Double-Blind Method
Gastric Fistula / drug therapy*
Intestinal Fistula / drug therapy*
Middle Aged
Octreotide / therapeutic use*
Randomized Controlled Trials as Topic
Reg. No./Substance:

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