Document Detail

Octreotide efficacy in the treatment of chylothoraces following cardiac surgery in infants and children.
MedLine Citation:
PMID:  16575348     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To examine the efficacy of octreotide in resolving chylothoraces in infants and children following cardiac surgery. DESIGN: Retrospective chart review. SETTING: Pediatric intensive care unit of a tertiary care center. PATIENTS: All children who received octreotide for the treatment of chylothoraces following surgery for congenital heart disease over a 30-month period between 2001-2004. INTERVENTIONS: Octreotide infusion. MEASUREMENTS AND MAIN RESULTS: Eight courses of octreotide treatment were identified in seven patients who met our inclusion criteria. The median duration of therapy was 5 days, and dosing ranged from 1 to 4 microg/kg/hr. Treatment did not result in an overall decrease in average chest tube output after 3 days of therapy. However, in two patients (29%) the chylothoraces ultimately resolved during the octreotide infusion. Treatment was well tolerated, and no serious side effects were noted. CONCLUSION: In contrast to previously published reports, we find octreotide therapy for postoperative chylothoraces to be successful in only a minority of cases.
Maple T Landvoigt; Charles J Mullett
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies     Volume:  7     ISSN:  1529-7535     ISO Abbreviation:  Pediatr Crit Care Med     Publication Date:  2006 May 
Date Detail:
Created Date:  2006-05-09     Completed Date:  2006-11-09     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100954653     Medline TA:  Pediatr Crit Care Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  245-8     Citation Subset:  IM    
Department of Internal Medicine, West Virginia University School of Medicine, Morgantown, WV, USA.
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MeSH Terms
Chylothorax / drug therapy*,  etiology
Drug Administration Schedule
Gastrointestinal Agents / administration & dosage,  therapeutic use*
Heart Defects, Congenital / surgery
Intensive Care Units
Octreotide / administration & dosage,  therapeutic use*
Postoperative Complications / drug therapy*
Retrospective Studies
Treatment Outcome
Reg. No./Substance:
0/Gastrointestinal Agents; 83150-76-9/Octreotide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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