| Octreotide and chylothorax. | |
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MedLine Citation:
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PMID: 16825878 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE OF REVIEW: This article reviews the current literature concerning the role of somatostatin and its synthetic analogue, octreotide, in the treatment of chylothorax. RECENT FINDINGS: Management of chylothorax includes evacuation of the pleural cavity through a chest tube to alleviate dyspnoea, and dietary fat restriction aimed at reducing lymph flow. When these measures fail to control lymph flow, surgical interventions are employed to achieve definite closure of the thoracic duct leak. Several case reports and series have shown that octreotide is safe and probably effective in both children and adults with chylothorax of different origins. The property of somatostatin and octreotide to induce leak closure is attributed to a decelerating effect on lymph flow, although their exact mechanism of action is not well defined. In successful cases, a substantial reduction of lymph drainage through the chest tube is evident within the first few days of commencing the drug, and treatment lasts for 1-2 weeks. Treatment failure has been also reported, however. SUMMARY: Accumulating evidence suggests that octreotide is a putative novel therapeutic intervention for chylothorax. It is imperative that randomized controlled studies are conducted in order to fully elucidate the efficacy and safety of this treatment. |
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Authors:
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Ioannis Kalomenidis |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Current opinion in pulmonary medicine Volume: 12 ISSN: 1070-5287 ISO Abbreviation: Curr Opin Pulm Med Publication Date: 2006 Jul |
Date Detail:
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Created Date: 2006-07-07 Completed Date: 2006-12-13 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9503765 Medline TA: Curr Opin Pulm Med Country: United States |
Other Details:
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Languages: eng Pagination: 264-7 Citation Subset: IM |
Affiliation:
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Department of Critical Care and Pulmonary Services, Athens Medical School, Evangelismos Hospital, Athens, Greece. jkalomenidis@hotmail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Child Chylothorax / drug therapy* Humans Lymph / physiology Octreotide / administration & dosage, therapeutic use* |
| Chemical | |
Reg. No./Substance:
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83150-76-9/Octreotide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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