Document Detail


Octreotide treatment of chylothorax in pediatric patients following cardiothoracic surgery.
MedLine Citation:
PMID:  21106017     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To analyze the efficacy and safety of octreotide treatment of persistent chylothorax in pediatric patients following cardiothoracic surgery.
DESIGN: Retrospective chart review of patients admitted to the cardiac intensive care unit of a tertiary care center over a 10-year period (1998-2008). Nineteen patients were identified who underwent treatment with octreotide for persistent chylothorax following cardiothoracic surgery. We analyzed data regarding age, sex, type of cardiac lesion and surgical procedure, postoperative day octreotide therapy was initiated, maximum drainage prior to and during octreotide therapy, dose range of octreotide, days to resolution, and complications.
RESULTS: Twelve patients (63%) experienced resolution of their chylothorax during octreotide treatment. Fourteen patients (74%) demonstrated a decrease in the peak effusion drainage rate following initiation of octreotide therapy, though two of these patients ultimately required further surgical intervention to achieve resolution. Octreotide treatment was associated with unchanged or increased effusion drainage rate in four patients (21%). Patients that responded to octreotide had a lower mean maximal drainage prior to octreotide initiation. Two patients experienced side effects temporally associated with octreotide therapy (transient hypoglycemia and diarrhea). No serious side effects were identified.
CONCLUSIONS: Octreotide treatment of chylothorax in combination with dietary modifications in pediatric patients following cardiothoracic surgery resulted in a reduction of peak effusion drainage and eventual resolution in the majority of cases with few and transient side effects.
Authors:
Lindsay Caverly; Christopher M Rausch; Eduardo da Cruz; Jon Kaufman
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Congenital heart disease     Volume:  5     ISSN:  1747-0803     ISO Abbreviation:  Congenit Heart Dis     Publication Date:    2010 Nov-Dec
Date Detail:
Created Date:  2010-11-25     Completed Date:  2011-03-10     Revised Date:  2011-05-05    
Medline Journal Info:
Nlm Unique ID:  101256510     Medline TA:  Congenit Heart Dis     Country:  United States    
Other Details:
Languages:  eng     Pagination:  573-8     Citation Subset:  IM    
Copyright Information:
© 2010 Copyright the Authors. Congenital Heart Disease © 2010 Wiley Periodicals, Inc.
Affiliation:
Department of Pediatrics, Division of Pediatric Cardiology, The Children's Hospital and The University of Colorado, The University of Colorado, Denver, Colo 80045, USA.
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MeSH Terms
Descriptor/Qualifier:
Cardiac Surgical Procedures / adverse effects*
Child, Preschool
Chylothorax / drug therapy*,  etiology
Colorado
Combined Modality Therapy
Diet, Fat-Restricted
Drainage
Female
Humans
Infant
Infant, Newborn
Intensive Care Units, Pediatric
Male
Nutritional Support
Octreotide / adverse effects,  therapeutic use*
Retrospective Studies
Thoracic Surgical Procedures / adverse effects*
Time Factors
Treatment Outcome
Chemical
Reg. No./Substance:
83150-76-9/Octreotide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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