| Octreotide treatment of chylothorax in pediatric patients following cardiothoracic surgery. | |
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MedLine Citation:
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PMID: 21106017 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To analyze the efficacy and safety of octreotide treatment of persistent chylothorax in pediatric patients following cardiothoracic surgery. DESIGN: Retrospective chart review of patients admitted to the cardiac intensive care unit of a tertiary care center over a 10-year period (1998-2008). Nineteen patients were identified who underwent treatment with octreotide for persistent chylothorax following cardiothoracic surgery. We analyzed data regarding age, sex, type of cardiac lesion and surgical procedure, postoperative day octreotide therapy was initiated, maximum drainage prior to and during octreotide therapy, dose range of octreotide, days to resolution, and complications. RESULTS: Twelve patients (63%) experienced resolution of their chylothorax during octreotide treatment. Fourteen patients (74%) demonstrated a decrease in the peak effusion drainage rate following initiation of octreotide therapy, though two of these patients ultimately required further surgical intervention to achieve resolution. Octreotide treatment was associated with unchanged or increased effusion drainage rate in four patients (21%). Patients that responded to octreotide had a lower mean maximal drainage prior to octreotide initiation. Two patients experienced side effects temporally associated with octreotide therapy (transient hypoglycemia and diarrhea). No serious side effects were identified. CONCLUSIONS: Octreotide treatment of chylothorax in combination with dietary modifications in pediatric patients following cardiothoracic surgery resulted in a reduction of peak effusion drainage and eventual resolution in the majority of cases with few and transient side effects. |
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Authors:
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Lindsay Caverly; Christopher M Rausch; Eduardo da Cruz; Jon Kaufman |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Congenital heart disease Volume: 5 ISSN: 1747-0803 ISO Abbreviation: Congenit Heart Dis Publication Date: 2010 Nov-Dec |
Date Detail:
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Created Date: 2010-11-25 Completed Date: 2011-03-10 Revised Date: 2011-05-05 |
Medline Journal Info:
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Nlm Unique ID: 101256510 Medline TA: Congenit Heart Dis Country: United States |
Other Details:
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Languages: eng Pagination: 573-8 Citation Subset: IM |
Copyright Information:
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© 2010 Copyright the Authors. Congenital Heart Disease © 2010 Wiley Periodicals, Inc. |
Affiliation:
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Department of Pediatrics, Division of Pediatric Cardiology, The Children's Hospital and The University of Colorado, The University of Colorado, Denver, Colo 80045, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Cardiac Surgical Procedures
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adverse effects* Child, Preschool Chylothorax / drug therapy*, etiology Colorado Combined Modality Therapy Diet, Fat-Restricted Drainage Female Humans Infant Infant, Newborn Intensive Care Units, Pediatric Male Nutritional Support Octreotide / adverse effects, therapeutic use* Retrospective Studies Thoracic Surgical Procedures / adverse effects* Time Factors Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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83150-76-9/Octreotide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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