Document Detail

Octreotide bolus injection and azygos blood flow in patients with cirrhosis: is the effect really predictable?
MedLine Citation:
PMID:  19996986     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Octreotide (OCT) improves the management of variceal bleeding, but the pattern of administration is not clearly defined. Available data show a transient decrease in portal pressure and azygos blood flow (AzBF) after OCT bolus injection with desensitization at readministration.
AIM: To explore the sustained hemodynamic effects of OCT and changes associated with readministration at 60 minutes on AzBF in patients with portal hypertension.
PATIENTS AND METHODS: AzBF was measured invasively (thermodilution technique) in 12 patients at baseline and at 10 minutes intervals after OCT 50-μg IV bolus for a total of 60 minutes. Readministration of OCT was followed by AzBF measurement for another 15 minutes. Patients [age 51.4 y (30 to 69)] had cirrhosis (alcoholic in 9 patients; Pugh's score 8.8±0.3), portal hypertension (HVPG 19±1 mm Hg), and elevated AzBF (658±138 mL/min).
RESULTS: The bolus of OCT was followed at 10 minutes by a 34% decline in AzBF as compared with baseline value. This AzBF reduction was sustained over the 60-minute study period (-36%±1.4%) with the values that remained decreased as compared with baseline (P<0.01). Mean arterial pressure remained stable. At 60 minutes, the repeat OCT bolus induced a further significant (P<0.01) decline in AzBF, although the response was blunted (-18%±1.2%).
CONCLUSION: The AzBF showed a sustained decrease of value after a bolus injection of 50-μg OCT. A further hemodynamic response is detectable at OCT readministration after 60 minutes. The pattern of hemodynamic response to OCT may not be uniform among cirrhotics.
Laurent Spahr; Emiliano Giostra; Gilles Mentha; Antoine Hadengue
Related Documents :
10463496 - Diminished vasoconstrictive function caused by long-term nonpulsatile left heart bypass.
464236 - Clinical significance of umbilicoportal manometry.
2591356 - The arterial supply of the navicular bone in adult horses with navicular disease.
1164236 - Tobramycin ototoxicity: a second look.
11973496 - Commercial airline travel decreases oxygen saturation in children.
23963046 - Acute cardiac and hemodynamic effects of sildenafil on resistant hypertension.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of clinical gastroenterology     Volume:  44     ISSN:  1539-2031     ISO Abbreviation:  J. Clin. Gastroenterol.     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-09-17     Completed Date:  2011-01-05     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7910017     Medline TA:  J Clin Gastroenterol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  e206-9     Citation Subset:  IM    
Gastroenterology and Hepatology Unit, University Hospitals, Geneva, Switzerland.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Azygos Vein / drug effects
Gastrointestinal Agents / administration & dosage,  pharmacology
Hypertension, Portal / drug therapy*,  physiopathology
Liver Cirrhosis / complications*,  drug therapy
Liver Cirrhosis, Alcoholic / complications
Middle Aged
Octreotide / administration & dosage,  pharmacology*
Portal Pressure / drug effects*
Time Factors
Reg. No./Substance:
0/Gastrointestinal Agents; 83150-76-9/Octreotide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Marked variations in proximal colon cancer survival by race/ethnicity within the United States.
Next Document:  Blood pressure response to potassium supplementation is associated with genetic variation in endothe...