| Octreotide bolus injection and azygos blood flow in patients with cirrhosis: is the effect really predictable? | |
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MedLine Citation:
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PMID: 19996986 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Octreotide (OCT) improves the management of variceal bleeding, but the pattern of administration is not clearly defined. Available data show a transient decrease in portal pressure and azygos blood flow (AzBF) after OCT bolus injection with desensitization at readministration. AIM: To explore the sustained hemodynamic effects of OCT and changes associated with readministration at 60 minutes on AzBF in patients with portal hypertension. PATIENTS AND METHODS: AzBF was measured invasively (thermodilution technique) in 12 patients at baseline and at 10 minutes intervals after OCT 50-μg IV bolus for a total of 60 minutes. Readministration of OCT was followed by AzBF measurement for another 15 minutes. Patients [age 51.4 y (30 to 69)] had cirrhosis (alcoholic in 9 patients; Pugh's score 8.8±0.3), portal hypertension (HVPG 19±1 mm Hg), and elevated AzBF (658±138 mL/min). RESULTS: The bolus of OCT was followed at 10 minutes by a 34% decline in AzBF as compared with baseline value. This AzBF reduction was sustained over the 60-minute study period (-36%±1.4%) with the values that remained decreased as compared with baseline (P<0.01). Mean arterial pressure remained stable. At 60 minutes, the repeat OCT bolus induced a further significant (P<0.01) decline in AzBF, although the response was blunted (-18%±1.2%). CONCLUSION: The AzBF showed a sustained decrease of value after a bolus injection of 50-μg OCT. A further hemodynamic response is detectable at OCT readministration after 60 minutes. The pattern of hemodynamic response to OCT may not be uniform among cirrhotics. |
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Authors:
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Laurent Spahr; Emiliano Giostra; Gilles Mentha; Antoine Hadengue |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of clinical gastroenterology Volume: 44 ISSN: 1539-2031 ISO Abbreviation: J. Clin. Gastroenterol. Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-09-17 Completed Date: 2011-01-05 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7910017 Medline TA: J Clin Gastroenterol Country: United States |
Other Details:
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Languages: eng Pagination: e206-9 Citation Subset: IM |
Affiliation:
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Gastroenterology and Hepatology Unit, University Hospitals, Geneva, Switzerland. Laurent.Spahr@hcuge.ch |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Azygos Vein / drug effects Female Gastrointestinal Agents / administration & dosage, pharmacology Hemodynamics Humans Hypertension, Portal / drug therapy*, physiopathology Liver Cirrhosis / complications*, drug therapy Liver Cirrhosis, Alcoholic / complications Male Middle Aged Octreotide / administration & dosage, pharmacology* Portal Pressure / drug effects* Thermodilution Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Gastrointestinal Agents; 83150-76-9/Octreotide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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