Document Detail


Octopamine-mediated circuit mechanism underlying controlled appetite for palatable food in Drosophila.
MedLine Citation:
PMID:  24003139     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The easy accessibility of energy-rich palatable food makes it difficult to resist food temptation. Drosophila larvae are surrounded by sugar-rich food most of their lives, raising the question of how these animals modulate food-seeking behaviors in tune with physiological needs. Here we describe a circuit mechanism defined by neurons expressing tdc2-Gal4 (a tyrosine decarboxylase 2 promoter-directed driver) that selectively drives a distinct foraging strategy in food-deprived larvae. Stimulation of this otherwise functionally latent circuit in tdc2-Gal4 neurons was sufficient to induce exuberant feeding of liquid food in fed animals, whereas targeted lesions in a small subset of tdc2-Gal4 neurons in the subesophageal ganglion blocked hunger-driven increases in the feeding response. Furthermore, regulation of feeding rate enhancement by tdc2-Gal4 neurons requires a novel signaling mechanism involving the VEGF2-like receptor, octopamine, and its receptor. Our findings provide fresh insight for the neurobiology and evolution of appetitive motivation.
Authors:
Ting Zhang; Audrey Branch; Ping Shen
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2013-09-03
Journal Detail:
Title:  Proceedings of the National Academy of Sciences of the United States of America     Volume:  110     ISSN:  1091-6490     ISO Abbreviation:  Proc. Natl. Acad. Sci. U.S.A.     Publication Date:  2013 Sep 
Date Detail:
Created Date:  2013-09-18     Completed Date:  2013-11-26     Revised Date:  2014-03-23    
Medline Journal Info:
Nlm Unique ID:  7505876     Medline TA:  Proc Natl Acad Sci U S A     Country:  United States    
Other Details:
Languages:  eng     Pagination:  15431-6     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Animals, Genetically Modified
Appetite Regulation / physiology*
Appetitive Behavior / physiology*
Biological Evolution
Drosophila / physiology*
Drosophila Proteins / metabolism
Immunohistochemistry
Larva / physiology
Neurons / metabolism*
Neuropeptide Y / metabolism
Octopamine / metabolism*
Real-Time Polymerase Chain Reaction
Receptors, G-Protein-Coupled / metabolism
Receptors, Vascular Endothelial Growth Factor / physiology*
Signal Transduction / physiology*
Transcription Factors / metabolism
Tyrosine Decarboxylase / metabolism
Grant Support
ID/Acronym/Agency:
DK058348/DK/NIDDK NIH HHS; R01-GM084947/GM/NIGMS NIH HHS
Chemical
Reg. No./Substance:
0/Drosophila Proteins; 0/GAL4 protein, Drosophila; 0/Neuropeptide Y; 0/Octbeta3 protein, Drosophila; 0/Receptors, G-Protein-Coupled; 0/Transcription Factors; 14O50WS8JD/Octopamine; EC 2.7.10.1/Receptors, Vascular Endothelial Growth Factor; EC 4.1.1.25/Tdc2 protein, Drosophila; EC 4.1.1.25/Tyrosine Decarboxylase
Comments/Corrections

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