Document Detail


Octanoic acid produces accumulation of monoamine acidic metabolites in the brain: interaction with organic anion transport at the choroid plexus.
MedLine Citation:
PMID:  1372345     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Effects of octanoic acid on monoamines and their acidic metabolites in the rat brain were analyzed by HPLC. Octanoic acid (1,000 mg/kg i.p.) elevated homovanillic acid levels by 54% in the caudate and 338% in the hypothalamus but increased 5-hydroxyindoleacetic acid (5-HIAA) levels in both the caudate and the hypothalamus by approximately 50% compared with the control. A lower dose of octanoic acid (500 mg/kg) increased 5-HIAA levels by 29% in the caudate and 20% in the hypothalamus. However, it did not produce any changes in the concentration of homovanillic acid in either the caudate or the hypothalamus. Treatment with octanoic acid also failed to change the level of dopamine, serotonin, and 3,4-dihydroxyphenylacetic acid in the caudate and the hypothalamus. The role of carrier-mediated transport in the clearance of 5-HIAA from the rabbit CSF was also evaluated in vivo by ventriculocisternal perfusion. Steady-state clearance of 5-HIAA from CSF exceeded that of inulin and was reduced in the presence of octanoic acid. Because this transport system in the choroid plexus is normally responsible for the excretion of the serotonin metabolite from the brain to the plasma, accumulation of endogenously produced organic acids in the brain, secondary to reduced clearance by the choroid plexus, could be a contributing factor in the development of encephalopathy in children with medium-chain acyl-CoA dehydrogenase deficiency who have elevated levels of octanoic acid systematically.
Authors:
C S Kim; C R Roe; J D Mann; G R Breese
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of neurochemistry     Volume:  58     ISSN:  0022-3042     ISO Abbreviation:  J. Neurochem.     Publication Date:  1992 Apr 
Date Detail:
Created Date:  1992-04-17     Completed Date:  1992-04-17     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  2985190R     Medline TA:  J Neurochem     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1499-503     Citation Subset:  IM    
Affiliation:
Department of Neurology, University of North Carolina School of Medicine, Chapel Hill.
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MeSH Terms
Descriptor/Qualifier:
Acids / metabolism*
Animals
Anions / metabolism
Biogenic Amines / metabolism*
Biological Transport
Brain / metabolism*
Choroid Plexus / metabolism*
Hydroxyindoleacetic Acid / pharmacokinetics
Male
Octanoic Acids / pharmacology*
Osmolar Concentration
Rats
Rats, Inbred Strains
Grant Support
ID/Acronym/Agency:
HD-03110/HD/NICHD NIH HHS
Chemical
Reg. No./Substance:
0/Acids; 0/Anions; 0/Biogenic Amines; 0/Octanoic Acids; 124-07-2/caprylic acid; 54-16-0/Hydroxyindoleacetic Acid
Comments/Corrections
Erratum In:
J Neurochem 1992 Jul;59(1):392

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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