Document Detail


Octanoic acid suppresses harmaline-induced tremor in mouse model of essential tremor.
MedLine Citation:
PMID:  22454323     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Recent work exploring the use of high-molecular weight alcohols to treat essential tremor (ET) has identified octanoic acid as a potential novel tremor-suppressing agent. We used an established harmaline-based mouse model of ET to compare tremor suppression by 1-octanol and octanoic acid. The dose-related effect on digitized motion power within the tremor bandwidth as a fraction of overall motion power was analyzed. Both 1-octanol and octanoic acid provided significant reductions in harmaline tremor. An 8-carbon alkyl alcohol and carboxylic acid each suppress tremor in a pre-clinical mouse model of ET. Further studies are warranted to determine the safety and efficacy of such agents in humans with ET.
Authors:
Fatta B Nahab; Adrian Handforth; Tyler Brown; Christopher Shin; Arnulfo Quesada; Chuanhui Dong; Dietrich Haubenberger; Mark Hallett
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics     Volume:  9     ISSN:  1878-7479     ISO Abbreviation:  Neurotherapeutics     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-09-14     Completed Date:  2013-02-15     Revised Date:  2014-09-21    
Medline Journal Info:
Nlm Unique ID:  101290381     Medline TA:  Neurotherapeutics     Country:  United States    
Other Details:
Languages:  eng     Pagination:  635-8     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Caprylates / therapeutic use*
Central Nervous System Stimulants / toxicity*
Disease Models, Animal
Dose-Response Relationship, Drug
Essential Tremor / chemically induced*,  drug therapy*
Harmaline / toxicity*
Male
Mice
Mice, Inbred ICR
Grant Support
ID/Acronym/Agency:
R01 NS073683/NS/NINDS NIH HHS; ZIA NS003032-04/NS/NINDS NIH HHS
Chemical
Reg. No./Substance:
0/Caprylates; 0/Central Nervous System Stimulants; 124-07-2/octanoic acid; CN58I4TOET/Harmaline
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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