| Octanoate transport in the isolated, perfused rat liver. | |
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MedLine Citation:
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PMID: 2667669 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The multiple indicator dilution technique was used to investigate octanoate transport in the isolated, perfused rat liver. The form of the octanoate outflow profiles depends on albumin concentration. The steady-state intracellular octanoate concentration and the rate of uptake increase when the albumin concentration is decreased. At physiological albumin concentrations, the intracellular concentration of octanoate is only 7% of the extracellular concentration. Exchange between the intra- and extracellular space, however, is very rapid, irrespective of the albumin concentration and consequently exchange is not rate limiting for metabolism. |
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Authors:
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J Constantin; M G Souza; O Ferraresi; M L Ferraresi; E L Ishii-Iwamoto; A Bracht |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Brazilian journal of medical and biological research = Revista brasileira de pesquisas médicas e biológicas / Sociedade Brasileira de Biofísica ... [et al.] Volume: 22 ISSN: 0100-879X ISO Abbreviation: Braz. J. Med. Biol. Res. Publication Date: 1989 |
Date Detail:
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Created Date: 1989-09-18 Completed Date: 1989-09-18 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8112917 Medline TA: Braz J Med Biol Res Country: BRAZIL |
Other Details:
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Languages: eng Pagination: 145-9 Citation Subset: IM |
Affiliation:
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Laboratório de Metabolismo Hepático, Universidade Estadual de Maringá, Brasil. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Albumins
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metabolism* Animals Caprylates / pharmacokinetics* Indicator Dilution Techniques Liver / metabolism* Mathematics Octanoic Acids / pharmacokinetics* Rats Time |
| Chemical | |
Reg. No./Substance:
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0/Albumins; 0/Caprylates; 0/Octanoic Acids; 124-07-2/caprylic acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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